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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Unusual tau in MSA.
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Unusual tau in MSA.

机译：MSA中异常的tau。

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A recent clinico-pathological study of seven cases of multiple system atrophy (MSA), in addition to characteristic morphology findings, revealed unusual tau-positive cyto-plasmic inclusions in astroglia, predominantly in the putamen, internal capsule and pontine basis. These lesions were particularly prominent in a woman aged 72 years who died 9 years after the onset of parkinsonism and ataxia. The detection of tau-positive granules not co-localized with alpha-synuclein (aSyn)-positive glial cyto-plasmic inclusions (GCI) in oligodendroglia, with more common expression of 4-repeat (R) than 3R tau, and related to the severity of neurodegeneration in MSA, suggested that tau may be related to a neurodegenerative pathway different from that induced by alphaSyn. These data could not be generally confirmed by a personal study of 44 autopsy-confirmed cases of MSA - 24 MSA-P and 20 MSA-C aged 51-72 (mean 61.0) years. Histological examination using routine stains and immunohistochem-istry for phosporylated tau (antibody AT 8, Innogenetics, Ghent, Belgium) and aSyn (rabbit polyclonal antibody, Chemicon, Temecula, CA, USA), was performed in all cases. In a single case of MSA-P, a man aged 67 years with 7 years duration of parkinsonism without cerebellar or gait disorders, in addition to striatonigral degeneration grade III without signs of olivopontocerebellar atrophy, tau-positive granules were detected in the cytoplasm of astroglia in the moderately degenerated putamen. These granules were AT8 immunoreactive and showed both RD3 and RD4 (repeat tau) immunopositivity, 4R tau being more common. These tau-positive cytoplasmic granules were observed only in proliferated astroglia, but not in oligodendroglia frequently involved by alphaSyn-positive GCIs. Tau-positive granules were not co-localized with GCIs and double-immunostaining showed no co-expression of tau and aSyn. The tau-positive glial granules were restricted to putamen, and neither similar glial inclusions nor any AT...
机译：最近对7例多系统萎缩（MSA）病例进行的临床病理研究表明，除了特征性形态学发现外，在星形胶质细胞中还存在异常的tau阳性细胞质内含物，主要存在于壳核，内囊和桥脑中。这些病变在帕金森病和共济失调发作后9年死亡的72岁女性中尤为突出。少突突胶质中不与α-突触核蛋白（aSyn）阳性神经胶质细胞质包涵体（GCI）共定位的tau阳性颗粒的检测，与3R tau相比，4重复（R）的表达更常见，与MSA中神经变性的严重性，提示tau可能与不同于alphaSyn诱导的神经变性途径有关。这些数据通常无法通过对44例经尸检确认的MSA病例进行个人研究来证实-24例MSA-P和20例51-72岁（平均61.0岁）的MSA-C。在所有情况下，均使用常规染色和免疫组化方法对磷酸化的tau（抗体AT 8，Innogenetics，比利时根特）和aSyn（兔多克隆抗体，Chemicon，Temecula，CA，美国）进行组织学检查。在MSA-P的一例中，一名67岁，帕金森病持续时间为7年，无小脑或步态障碍的人，除了三级纹状体变性，无小脑小脑萎缩的迹象外，在星形胶质细胞质中还检测到tau阳性颗粒在中等程度退化的壳核中。这些颗粒具有AT8免疫反应性，并显示RD3和RD4（重复tau）免疫阳性，而4R tau更常见。这些tau阳性细胞质颗粒仅在增生的星形胶质细胞中观察到，而在αSyn阳性GCI经常涉及的少突胶质细胞中未观察到。 Tau阳性颗粒未与GCI共同定位，双重免疫染色未显示tau和aSyn的共表达。 tau阳性神经胶质颗粒仅限于壳核，并且没有相似的神经胶质包裹体或任何AT ...

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