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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Pleomorphic pineocytoma associated with normal pineal parenchyma: report of a case in a 70-year-old man.
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Pleomorphic pineocytoma associated with normal pineal parenchyma: report of a case in a 70-year-old man.

机译：多形性松果细胞瘤与正常的松果体薄壁瘤相关：一个70岁男子的病例报道。

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摘要

Pineocytomas (PCs) most frequently occur in adults, but only three cases have been reported in women older than 70 years. In PCs, cytologic pleomorphism, accompanied by ganglion cells intensely expressing neuronal markers, has been described and the presence of pleomorphic cells may lead to an erroneous upgrading of the tumor. We report an unusual case of pleomorphic pineocytoma in an older patient who presented with a slowly growing tumor adjacent to residual pineal gland. The immunohistological markers of the tumoral tissue and the remnant normal pineal tissue were evaluated and compared. In the neoplasm, the large number of cells labeled for neuronal markers, including many pleomorphic cells, confirmed previous findings that a neuronal immunophenotype is common in PC. Reactivity for synaptophysin was stronger in the tumor than the pineal gland, whereas neurofilament protein reactivity was stronger in the pineal gland than the tumor. The neoplastic cells, but not the pineal gland, were reactive for chromogranin A. This dense core vesicle-associated protein immunolabeling is an interesting diagnostic marker for PCs, which makes it possible to distinguish normal pineal parenchyma with low or negative expression from tumoral tissue. This case illustrates that, even though PCs are low-grade tumors, they can increase in size and surgery appears a valuable option.
机译：松果细胞瘤（PCs）最常见于成人，但70岁以上的女性仅报道三例。在PC中，已经描述了细胞学多态性，伴随着强烈表达神经元标志物的神经节细胞，并且多态性细胞的存在可能导致肿瘤的错误升级。我们报道了一名老年患者的多形性胞浆瘤的不寻常病例，该患者出现了与残留松果体相邻的缓慢生长的肿瘤。评价并比较了肿瘤组织和残余正常松果组织的免疫组织学标记。在肿瘤中，标记有神经元标记物的大量细胞，包括许多多形性细胞，证实了先前的发现，即神经元免疫表型在PC中很常见。肿瘤中对突触素的反应性比松果体强，而松果体中的神经丝蛋白反应性比肿瘤强。肿瘤细胞对嗜铬粒蛋白A具有反应性，但对松果体无反应。这种致密的核心囊泡相关蛋白免疫标记是PCs的有趣诊断标记，这使得从肿瘤组织中区分出低表达或阴性表达的正常松果体实质成为可能。这个案例说明，即使PC是低度肿瘤，它们也可能会增大尺寸，而外科手术似乎是一种有价值的选择。

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