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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas
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Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas

机译：IDH1，MGMT和P53的免疫组织化学谱：对弥漫性神经胶质瘤患者预后的现实意义

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摘要

Genetic and epigenetic status, including mutations of isocitrate dehydrogenase (IDH) and TP53 and methylation of O-6-methylguanine-DNA methyltransferase (MGMT), are associated with the development of various types of glioma and are useful for prognostication. Here, using routinely available histology sections from 312 patients with diffuse gliomas, we performed immunohistochemistry using antibodies specific for IDH1 mutation, MGMT methylation status, and aberrant p53 expression to evaluate the possible prognostic significance of these features. With regard to overall survival (OS), univariate analysis indicated that an IDH1-positive profile in patients with glioblastoma (GBM), anaplastic astrocytoma (AA), anaplastic oligoastrocytoma and oligodendroglioma, or a MGMT-negative profile in patients with GBM and AA were significantly associated with a favorable outcome. Multivariate analysis revealed that both profiles were independent factors influencing prognosis. The OS of patients with IDH1-positive/MGMT-negative profiles was significantly longer than that of patients with negativeegative and negative/positive profiles. A p53 profile was not an independent prognostic factor. However, for GBM/AA patients with IDH1-negative/MGMT-negative profiles, p53 overexpression was significantly associated with an unfavorable outcome. Thus, the immunohistochemical profiles of IDH1 and MGMT are of considerable significance in gliomas, and a combination of IDH1, MGMT and p53 profiles may be useful for prognostication of GBM/AA.
机译：遗传和表观遗传状态，包括异柠檬酸脱氢酶（IDH）和TP53的突变以及O-6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的甲基化，与各种类型的神经胶质瘤的发生有关，可用于预后。在这里，我们使用来自312例弥漫性胶质瘤患者的常规组织学切片，使用针对IDH1突变，MGMT甲基化状态和异常p53表达的特异性抗体进行免疫组织化学，以评估这些特征的可能预后意义。关于总生存期（OS），单因素分析表明，胶质母细胞瘤（GBM），间变性星形细胞瘤（AA），间变性少星形细胞瘤和少突胶质细胞瘤患者的IDH1阳性特征为GBM和AA患者的MGMT阴性特征与良好的结果显着相关。多变量分析表明，这两种情况都是影响预后的独立因素。 IDH1阳性/ MGMT阴性的患者的OS明显长于阴性/阴性和阴性/阳性的患者。 p53谱不是独立的预后因素。但是，对于IDH1阴性/ MGMT阴性的GBM / AA患者，p53过表达与不良的预后显着相关。因此，IDH1和MGMT的免疫组织化学谱在神经胶质瘤中具有相当重要的意义，IDH1，MGMT和p53谱的组合可能对GBM / AA的预后有用。

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