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首页> 外文期刊>Neuron >Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells
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Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells

机译：小鼠胚胎干细胞衍生的皮层神经元对成人大脑皮层受损电路的区域特定重建

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摘要

Pluripotent stem-cell-derived neurons constitute an attractive source for replacement therapies, but their utility remains unclear for cortical diseases. Here, we show that neurons of visual cortex identity, differentiated in vitro from mouse embryonic stem cells (ESCs), can be transplanted successfully following a lesion of the adult mouse visual cortex. Reestablishment of the damaged pathways included long-range and reciprocal axonal projections and synaptic connections with targets of the damaged cortex. Electrophysiological recordings revealed that some grafted neurons were functional and responsive to visual stimuli. No significant integration was observed following grafting of the same neurons in motor cortex, or transplantation of embryonic motor cortex in visual cortex, indicating that successful transplantation required a match in the areal identity of grafted and lesioned neurons. These findings demonstrate that transplantation of mouse ESC-derived neurons of appropriate cortical areal identity can contribute to the reconstruction of an adult damaged cortical circuit.
机译：多能干细胞来源的神经元是替代疗法的诱人来源，但对于皮质疾病其用途仍不清楚。在这里，我们显示了视觉皮层身份的神经元，在体外与小鼠胚胎干细胞（ESCs）分化，可以在成年小鼠视觉皮层病变后成功移植。受损路径的重建包括远距离和相互的轴突投射以及与受损皮层目标的突触连接。电生理记录显示，某些嫁接的神经元具有功能并对视觉刺激作出反应。在运动皮层中移植相同的神经元，或在视觉皮层中移植胚胎运动皮层后，未观察到明显的整合，这表明成功的移植需要移植的和病变的神经元的面积相同。这些发现表明，移植具有适当皮质区域身份的小鼠ESC来源的神经元可有助于重建成年受损的皮质回路。

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