Wiring the Vascular Network with Neural Cues: A CNS Perspective

Waelchli Thomas; Wacker Andrin; Frei Karl; Regli Luca; Schwab Martin E.; Hoerstrup Simon P.; Gerhardt Holger; Engelhardt Britta

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Wiring the Vascular Network with Neural Cues: A CNS Perspective

机译：用神经线索连接血管网络：CNS的观点

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The vascular and the nervous system are responsible for oxygen, nutrient, and information transfer and thereby constitute highly important communication systems in higher organisms. These functional similarities are reflected at the anatomical, cellular, and molecular levels, where common developmental principles and mutual crosstalks have evolved to coordinate their action. This resemblance of the two systems at different levels of complexity has been termed the "neurovascular link." Most of the evidence demonstrating neurovascular interactions derives from studies outside the CNS and from the CNS tissue of the retina. However, little is known about the specific properties of the neurovascular link in the brain. Here, we focus on regulatory effects of molecules involved in the neurovascular link on angiogenesis in the periphery and in the brain and distinguish between general and CNS-specific cues for angiogenesis. Moreover, we discuss the emerging molecular interactions of these angiogenic cues with the VEGF-VEGFR-Delta-like ligand 4 (Dll4)-Jagged-Notch pathway.

机译：血管和神经系统负责氧气，营养物和信息的传递，因此在高等生物中构成高度重要的通讯系统。这些功能上的相似性反映在解剖学，细胞和分子水平上，在这些水平上，共同的发展原理和相互串扰已经演变为协调其作用。这两个系统在不同复杂程度上的相似之处被称为“神经血管联系”。证明神经血管相互作用的大多数证据均来自CNS外部的研究以及视网膜的CNS组织。但是，关于大脑中神经血管连接的特定属性知之甚少。在这里，我们专注于参与神经血管连接的分子对周围和大脑血管生成的调控作用，并区分一般的和CNS特异性的血管生成提示。此外，我们讨论了这些血管生成线索与VEGF-VEGFR-Delta样配体4（Dll4）-锯齿状Notch途径的新兴分子相互作用。

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《Neuron》 |2015年第2期|共26页
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Waelchli Thomas; Wacker Andrin; Frei Karl; Regli Luca; Schwab Martin E.; Hoerstrup Simon P.; Gerhardt Holger; Engelhardt Britta;
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正文语种 eng
中图分类神经病学;
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1. Wiring the Vascular Network with Neural Cues: A CNS Perspective [J] . Waelchli Thomas, Wacker Andrin, Frei Karl, Neuron . 2015,第2期

机译：用神经线索连接血管网络：CNS的观点
2. Groundwater level forecasting with artificial neural networks: a comparison of long short-term memory (LSTM), convolutional neural networks (CNNs), and non-linear autoregressive networks with exogenous input (NARX) [J] . Wunsch Andreas, Liesch Tanja, Broda Stefan Hydrology and Earth System Sciences Discussions . 2021,第3期

机译：与人工神经网络的地下水位预测：具有外源输入（NARX）的长短期记忆（LSTM），卷积神经网络（CNNS）和非线性自回归网络的比较
3. Groundwater level forecasting with artificial neural networks: a comparison of long short-term memory (LSTM), convolutional neural networks (CNNs), and non-linear autoregressive networks with exogenous input (NARX) [J] . Wunsch Andreas, Liesch Tanja, Broda Stefan Hydrology and Earth System Sciences . 2021,第3期

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4. Cellular neural network friendly convolutional neural networks — CNNs with CNNs [C] . András Horváth, Michael Hillmer, Qiuwen Lou, Design, Automation Test in Europe Conference Exhibition . 2017

机译：细胞神经网络友好的卷积神经网络—带有CNN的CNN
5. Cues for cellular assembly of vascular elastin networks. [D] . Kothapalli, Chandrasekhar R. 2008

机译：提示血管弹性蛋白网络的细胞组装。
6. Tell Me What Do You See?—Interpretable Classification of Wiring Harness Branches with Deep Neural Networks [O] . Piotr Kicki, Michał Bednarek, Paweł Lembicz, 2021

机译：告诉我你看到了什么？ - 具有深度神经网络的接线线束分支的interpretable分类
7. Wiring the Vascular Network with Neural Cues: A CNS Perspective [O] . Wälchli, Thomas, Wacker, Andrin, Frei, Karl, 2015

机译：用神经线索连接血管网络：CNS的观点

Wiring the Vascular Network with Neural Cues: A CNS Perspective

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