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首页> 外文期刊>Neuron >Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position
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Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position

机译：Satb2是开发可调节肢体位置的脊柱外感受微电路所必需的

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摘要

Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. Both the cellular components and the molecular mechanisms that instruct the assembly of the spinal sensorimotor system are poorly understood. Here we characterize the connectivity pattern of a sub-population of lamina V inhibitory sensory relay neurons marked during development by the nuclear matrix and DNA binding factor Satb2 (ISRSatb2). ISRSatb2 neurons receive inputs from multiple streams of sensory information and relay their outputs to motor command layers of the spinal cord. Deletion of the Satb2 transcription factor from ISRSatb2 neurons perturbs their cellular position, molecular profile, and pre-and post-synaptic connectivity. These alterations are accompanied by abnormal limb hyperflexion responses to mechanical and thermal stimuli and during walking. Thus, Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network.
机译：诸如步行或使肢体脱离疼痛刺激之类的运动行为依赖于集成的多峰感觉电路来生成适当的肌肉激活模式。指导脊髓感觉运动系统组装的细胞成分和分子机制都知之甚少。在这里，我们表征了在发展过程中被核基质和DNA结合因子Satb2（ISRSatb2）标记的层板V抑制感官中继神经元亚群的连接模式。 ISRSatb2神经元接收来自多个感官信息流的输入，并将其输出中继到脊髓的运动命令层。从ISRSatb2神经元中删除Satb2转录因子会扰乱其细胞位置，分子谱以及突触前后的连通性。这些改变伴有对机械和热刺激以及步行过程中异常的肢体过度弯曲反应。因此，Satb2是遗传决定因素，介导核心感觉到运动的脊髓网络中的适当电路发育。

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