Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.

Hamann Martine; Rossi DavidJ; Attwell David

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Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.

机译：补剂和溢出抑制颗粒细胞控制信息流经小脑皮质。

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We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABA(A) receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.

机译：我们显示信息流经成年的小脑皮质，从长满苔藓的纤维输入到浦肯野细胞输出，是由速尿敏感，对地西steroid和对神经固醇不敏感的颗粒细胞上的GABA（A）受体控制的，这些受体在声调和由GABA从突触释放部位溢出。与通过高频刺激突触释放的GABA相比，这些受体的强直激活贡献的平均抑制电导率高3倍。进补和溢出抑制作用减少了由苔藓纤维输入激活的颗粒细胞的比例，从而增加了编码稀疏度，这有望提高小脑的信息存储能力。

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《Neuron》 |2002年第4期|共9页
作者
Hamann Martine; Rossi DavidJ; Attwell David;
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正文语种 eng
中图分类神经生理学;
关键词
Cerebellar Cortex; Neural Inhibition; Neurons; Receptors; GABA-A; Synapses; 小脑皮质; 神经抑制; 神经元; 受体; GABA-A; 突触; 突触传递;

机译：Cerebellar Cortex;Neural Inhibition;Neurons;Receptors;GABA-A;Synapses;小脑皮质;神经抑制;神经元;受体;GABA-A;突触;突触传递;

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专利

1. Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. [J] . Hamann Martine, Rossi DavidJ, Attwell David Neuron . 2002,第4期

机译：补剂和溢出抑制颗粒细胞控制信息流经小脑皮质。
2. ASTROCYTIC ALDH2 REGULATES ETHANOL ENHANCEMENT OF GABAERGIC TONIC INHIBITION OF CEREBELLAR GRANULE CELLS [J] . Jin S., Yang F., Luo G., Alcoholism: Clinical and experimental research . 2019,第S1期

机译：星形胶质组织ALDH2调节乙醇增强大肠杆菌颗粒细胞的加法抑制
3. Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells. [J] . Leao RM, Mellor JR, Randall AD Neuropharmacology . 2000,第6期

机译：滋补苯二氮卓类药物对培养的啮齿动物小脑颗粒细胞中GABA的抑制作用。
4. Dependence of cerebellar module information storage parameters on properties of mossy fibers-Granule cells connection matrix [C] . Buharin, E.V., Dunin-Barkowski, . 1992

机译：小脑模块信息存储参数对苔藓纤维性质的依赖性-颗粒细胞连接矩阵
5. Genetic control of cerebellar granule cell production and cerebellar morphogenesis by murine zinc finger transcription factor Ru49. [D] . Yang, Xiangdong William. 1998

机译：鼠锌指转录因子Ru49对小脑颗粒细胞产生和小脑形态发生的遗传控制。
6. Na+/K+-ATPase Inhibition Partially Mimics the Ethanol-Induced Increase of the Golgi Cell-Dependent Component of the Tonic GABAergic Current in Rat Cerebellar Granule Cells [O] . Marvin R. Diaz, Aya Wadleigh, Shyam Kumar, 2010

机译：Na + / K + -ATPase抑制作用部分模拟了乙醇诱导的大鼠小脑颗粒细胞强直性GABA能电流的高尔基体细胞依赖性成分的增加。
7. Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex [O] . Hamann, M., Rossi, D. J., Attwell, David 2002

机译：抑制颗粒细胞的滋补和溢出控制通过小脑皮质的信息流

Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.

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