The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons.

Krueger SR; Kolar A; Fitzsimonds RM

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The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons.

机译：突触前释放装置在没有树突状接触且在孤立的轴突内高度移动的情况下起作用。

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Whether contact of an axon with a dendrite is a necessary inductive signal for the assembly of functional presynaptic machinery is controversial. Combining FM1-43 imaging with retrospective immunocytochemistry, we observe many functional synaptic vesicle (SV) release sites lacking postsynaptic specializations in cultured hippocampal neurons. These orphan endocytic recycling as mature synaptic sites. Moreover, quantitative analysis of FM1-43 destaining at these orphan release sites reveals similar kinetics with slightly lower release probabilities. Time-lapse imaging of FM1-43 reveals that orphans are generated by complete or partial mobilization of synaptic release sites that retain their functionality in transit. Orphan clusters fuse with existing synaptic release sites or form novel release sites onto dendrites. Mobilization and stabilization of orphan boutons to new sites of dendritic contact may represent a necessary presynaptic counterpart to postsynaptic changes observed during development and plasticity in the CNS.

机译：轴突与树突的接触是否是组装功能性突触前机械所必需的感应信号是有争议的。 FM1-43成像与回顾性免疫细胞化学相结合，我们观察到在培养的海马神经元中缺乏突触后专业化的许多功能性突触小泡（SV）释放位点。这些孤儿内吞再循环为成熟的突触位点。此外，对在这些孤儿释放位点脱色的FM1-43的定量分析显示出类似的动力学，释放概率略低。 FM1-43的延时成像显示，孤儿是通过完全或部分动员突触释放位点而生成的，这些位点保留了转运中的功能。孤儿簇与现有的突触释放位点融合或在树突上形成新的释放位点。孤儿动臂的动员和稳定到树突状接触的新位点可能代表在CNS发育和可塑性过程中观察到的突触后变化的必要突触前对应物。

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《Neuron》 |2003年第5期|共13页
作者
Krueger SR; Kolar A; Fitzsimonds RM;
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正文语种 eng
中图分类基础医学;
关键词
Discharge (release); Orphans; FM1 43; Axons; Release brand abscission agent; 轴突;

机译：放电（释放）;孤儿;FM1 43;轴突;发布品牌脱落剂;轴突;

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1. The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons. [J] . Krueger SR, Kolar A, Fitzsimonds RM Neuron . 2003,第5期

机译：突触前释放装置在没有树突状接触且在孤立的轴突内高度移动的情况下起作用。
2. Do-it-yourself tiling: dendritic growth in the absence of homotypic contacts. [J] . Logan MA, Vetter ML Neuron . 2004,第4期

机译：自己动手拼贴：在没有同型接触的情况下树突状生长。
3. Atomically Isolated Rh Sites within Highly Branched Rh_2Sb Nanostructures Enhance Bifunctional Hydrogen Electrocatalysis [J] . Zhang Ying, Li Gen, Zhao Zhonglong, Advanced Materials . 2021,第43期

机译：高分分支RH_2SB纳米结构中的原子分离的RH位点增强双官能氢电催化
4. SYNTHESIS OF AZOBENZENE FUNCTIONALIZED DENDRITIC BLOCK COPOLYMER BASED ON HYPERBRANCHED PDMAEMA AND INVESTIGATION OF ITS DRUG RELEASE PROPERTIES [C] . Minying Xing, Weihua Guo, Zhenping Cheng, Symposium on innovative polymers for controlled delivery: Abstract book. . 2010

机译：基于超支化的间苯二酚的偶氮苯功能化树枝状嵌段共聚物的合成及其药物释放性能的研究
5. The absence of calcium blocks impulse-evoked release of acetylcholine but not de novo formation of functional neuromuscular synaptic contacts in culture [O] . LP Henderson, MA Smith, NC Spitzer 1984

机译：钙的缺乏会阻止培养物中乙酰胆碱的脉冲诱发释放但不能从头开始形成功能性神经肌肉突触接触
6. The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons [O] . Krueger Stefan R., Kolar Annette, Fitzsimonds Reiko Maki 2003

机译：突触前释放装置在没有树突状接触且在孤立的轴突内高度移动的情况下起作用
7. Mobile Phase in Coals: Its Nature and Modes of Release: A Study of the Molybdenum Catalyzed Hydrogenation of Coals in the Absence of Solvent: Final Report, Part 3 [R] . Stansberry, P. G. , Derbyshire, F. J. 1988

机译：煤中的流动相：其性质和释放方式：在没有溶剂的情况下钼催化加氢的研究：最终报告，第3部分

The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons.

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