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首页> 外文期刊>Neuron >Conserved roles for Slit and Robo proteins in midline commissural axon guidance.
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Conserved roles for Slit and Robo proteins in midline commissural axon guidance.

机译：Slit和Robo蛋白在中线连合轴突引导中的保守作用。

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摘要

In Drosophila, Slit at the midline activates Robo receptors on commissural axons, thereby repelling them out of the midline into distinct longitudinal tracts on the contralateral side of the central nervous system. In the vertebrate spinal cord, Robo1 and Robo2 are expressed by commissural neurons, whereas all three Slit homologs are expressed at the ventral midline. Previous analysis of Slit1;Slit2 double mutant spinal cords failed to reveal a defect in commissural axon guidance. We report here that when all six Slit alleles are removed, many commissural axons fail to leave the midline, while others recross it. In addition, Robo1 and Robo2 single mutants show guidance defects that reveal a role for these two receptors in guiding commissural axons to different positions within the ventral and lateral funiculi. These results demonstrate a key role for Slit/Robo signaling in midline commissural axon guidance in vertebrates.
机译：在果蝇中，中线处的裂隙会激活连合轴突上的Robo受体，从而将它们从中线排斥到中枢神经系统对侧的不同纵向束中。在脊椎动物的脊髓中，Robo1和Robo2由连合神经元表达，而所有三个Slit同源物均在腹中线表达。先前对Slit1; Slit2双突变型脊髓的分析未能揭示连合轴突引导的缺陷。我们在这里报告说，当所有六个狭缝等位基因都被去除时，许多连合轴突无法离开中线，而其他轴突则重新穿过中线。此外，Robo1和Robo2单个突变体显示出指导缺陷，揭示了这两种受体在将连合轴突引导至腹侧和侧耳内的不同位置的作用。这些结果证明了裂隙/机器人信号在脊椎动物中线连合轴突引导中的关键作用。

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