...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >A molecular mechanism for stabilization of learning-induced synaptic modifications.
【24h】

A molecular mechanism for stabilization of learning-induced synaptic modifications.

机译：稳定学习诱导的突触修饰的分子机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acquire a successful behavioral strategy (rule learning), followed by an NMDAR-insensitive phase in which the animals learn to distinguish between individual odors (pair learning). Rule learning regulates the composition of synaptic NMDARs in the piriform cortex, resulting in receptors with a higher complement of the NR2a subunit protein relative to NR2b. Rule learning also reduces long-term potentiation (LTP) induced by high-frequency stimulation of the intracortical axons in slices of piriform cortex. As NR2a-containing NMDARs mediate shorter excitatory postsynaptic currents than those containing NR2b, we suggest that learning-induced regulation of NMDAR composition constrains subsequent synaptic plasticity, thereby maintaining the memory encoded by experience.
机译：嗅觉是啮齿动物的主要感觉方式，大鼠很快学会辨别气味并将气味与奖励联系起来。在这里，我们表明，这种嗅觉歧视（OD）学习由两个具有不同细胞机制的阶段组成：初始NMDAR敏感阶段，其中动物获得成功的行为策略（规则学习），其次是NMDAR不敏感阶段，其中动物动物学会区分个别气味（配对学习）。规则学习可调节梨状皮层中突触NMDAR的组成，从而使受体的NR2a亚基蛋白相对于NR2b具有更高的互补性。规则学习还可以减少高频刺激，该刺激是由梨状皮层切片中的皮质内轴突的高频刺激引起的。由于含NR2a的NMDAR介导的兴奋性突触后电流短于含NR2b的NMDAR，因此我们建议学习诱导的NMDAR组成的调控会限制随后的突触可塑性，从而保持经验编码的记忆。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号