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首页> 外文期刊>Neuron >Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.
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Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.

机译：急性多巴胺依赖的运动功能障碍期间皮质口角膜集合协调的快速变化。

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Dopaminergic dysregulation can cause motor dysfunction, but the mechanisms underlying dopamine-related motor disorders remain under debate. We used an inducible and reversible pharmacogenetic approach in dopamine transporter knockout mice to investigate the simultaneous activity of neuronal ensembles in the dorsolateral striatum and primary motor cortex during hyperdopaminergia ( approximately 500% of controls) with hyperkinesia, and after rapid and profound dopamine depletion (<0.2%) with akinesia in the same animal. Surprisingly, although most cortical and striatal neurons ( approximately 70%) changed firing rate during the transition between dopamine-related hyperkinesia and akinesia, the overall cortical firing rate remained unchanged. Conversely, neuronal oscillations and ensemble activity coordination within and between cortex and striatum did change rapidly between these periods. During hyperkinesia, corticostriatal activity became largely asynchronous, while during dopamine-depletion the synchronicity increased. Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits.
机译：多巴胺能失调可引起运动功能障碍，但与多巴胺相关的运动障碍的潜在机制仍存在争议。我们在多巴胺转运蛋白敲除小鼠中使用了一种可诱导和可逆的药物遗传学方法，研究了多巴胺过多症（运动前后）以及快速而深刻的多巴胺耗竭（ 0.2％）患有同一动物的运动障碍。令人惊讶的是，尽管大多数皮质和纹状体神经元（约70％）在多巴胺相关的运动亢进和运动障碍之间过渡期间改变了放电速率，但总体皮质放电速率保持不变。相反，在这些时期之间，皮层和纹状体之间以及之间的神经元振荡和整体活动协调性确实发生了快速变化。在运动亢进期间，皮层皮质神经活动在很大程度上变得异步，而在多巴胺消耗期间，同步性增加。因此，像帕金森氏病这样的多巴胺相关疾病可能不是皮质活动总体水平的变化，而是皮质皮质循环中功能失调。

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