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首页> 外文期刊>Neuron >Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior.
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Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior.

机译：探索性行为中尖峰波/波纹网络模式期间，CA1锥体细胞的位置选择性激发。

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摘要

We observed sharp wave/ripples (SWR) during exploration within brief (<2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a supralinear with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.
机译：我们在θ振荡的短暂中断（<2.4 s）内或θ振荡过程中观察到了尖锐的波纹/波纹（SWR）。探索期间发生的SWR的CA1网络响应（eSWR）与醒来的不动或睡眠中检测到的SWR相似。但是，eSWR期间的神经元活动与位置有关，并且与eSWR相关的放电在放置区域内部比在外部区域更强。与外部相比，与eSPW相关的发射增加要强于内部的基线增加，这表明具有类似位置场的超线性和/或勘探期间的相关发射显示出在eSWR和随后的睡眠SWR中较强的共激活性。唤醒共点火模式不需要重新激活位置细胞。具有对称互相关的细胞对在睡眠SWR期间仍显示出重新激活的唤醒共点火模式。我们建议在eSWR期间进行位置选择激发可促进具有相似位置字段的单元之间的初始关联，从而使与位置相关的集成模式可以在后续的睡眠SWR中重现。

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