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首页> 外文期刊>Neuron >Temporal encoding of place sequences by hippocampal cell assemblies.
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Temporal encoding of place sequences by hippocampal cell assemblies.

机译：海马细胞装配体对位置序列的时间编码。

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摘要

Both episodic memory and spatial navigation require temporal encoding of the relationships between events or locations. In a linear maze, ordered spatial distances between sequential locations were represented by the temporal relations of hippocampal place cell pairs within cycles of theta oscillation in a compressed manner. Such correlations could arise due to spike "phase precession" of independent neurons driven by common theta pacemaker or as a result of temporal coordination among specific hippocampal cell assemblies. We found that temporal correlation between place cell pairs was stronger than predicted by a pacemaker drive of independent neurons, indicating a critical role for synaptic interactions and precise timing within and across cell assemblies in place sequence representation. CA1 and CA3 ensembles, identifying spatial locations, were active preferentially on opposite phases of theta cycles. These observations suggest that interleaving CA3 neuronal sequences bind CA1 assemblies representing overlapping past, present, and future locations into single episodes.
机译：情景记忆和空间导航都需要对事件或位置之间的关系进行时间编码。在线性迷宫中，连续位置之间有序的空间距离由theta振荡周期内海马位置细胞对的时间关系以压缩方式表示。这种相关性可能是由于由共同theta起搏器驱动的独立神经元的尖峰“相位进动”或特定海马细胞组件之间的时间协调而产生的。我们发现，位置细胞对之间的时间相关性比独立神经元的起搏器驱动所预测的要强，这表明突触相互作用和位置序列表示中细胞组件内部和之间的精确定时至关重要。识别空间位置的CA1和CA3集合优先在theta循环的相反相位上活动。这些观察结果表明交错的CA3神经元序列将代表重叠的过去，现在和将来位置的CA1程序集绑定为单个事件。

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