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首页> 外文期刊>Neuron >Inducible and cell-type restricted manipulation in the entorhinal cortex.
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Inducible and cell-type restricted manipulation in the entorhinal cortex.

机译:内嗅皮层中的诱导型和细胞型限制操作。

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The entorhinal cortex functions as the gateway to the hippocampal formation. However, its role in formation and consolidation of hippocampus-dependent memory remains relatively unexplored. In this issue of Neuron, Yasuda and Mayford report an elegant cell-type restricted inducible transgenic mouse overexpressing a mutant form of CaM kinase II selectively in superficial layers of medial entorhinal cortex and its upstream regions. These animals display a selective spatial memory deficit during the immediate posttraining period as well as during acquisition in the Morris water maze. Similar to the hippocampus, this time-limited involvement of entorhinal cortex in spatial memory processing suggests a crucial role for hippocampal-entorhinal circuitry in spatial memory formation.
机译:内嗅皮层充当通往海马结构的通道。但是,其在海马依赖性记忆的形成和巩固中的作用仍未被探索。在本期《神经元》中,Yasuda和Mayford报告了一种优雅的细胞类型受限诱导型转基因小鼠,在内侧内嗅皮层及其上游区域的表层选择性表达过表达CaM激酶II的突变形式。这些动物在训练后立即以及在莫里斯水迷宫中采集期间表现出选择性的空间记忆缺陷。与海马相似,内嗅皮层在空间记忆过程中的这种有限时间的参与暗示了海马-肠内神经回路在空间记忆形成中的关键作用。

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