Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

Plath N; Ohana O; Dammermann B; Errington ML; Schmitz D; Gross C; Mao X; Engelsberg A; Mahlke C; Welzl H; Kobalz U; Stawrakakis A; Fernandez E; Waltereit R; Bick-Sander A; Therstappen E; Cooke SF; Blanquet V; Wurst W; Salmen B; Bosl MR; Lipp HP; Seth G.N. Grant; Tim V.P. Bliss; David P. Wolfer; Dietmar Kuhl

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Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

机译：Arc / Arg3.1对于巩固突触可塑性和记忆至关重要。

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Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.

机译：Arc / Arg3.1被可塑性产生的刺激强烈诱导，并且特别针对刺激的突触区域。为了研究Arc / Arg3.1在突触可塑性和学习记忆中的作用，我们生成了Arc / Arg3.1基因敲除小鼠。尽管完整的短期记忆，这些动物无法形成对内隐和外显学习任务的持久记忆。此外，它们在齿状回和CA1区表现出海马长期增强的双相变化，早期和后期均增强。另外，长期抑郁症明显受损。总之，这些结果证明了Arc / Arg3.1在持久的突触可塑性和记忆存储整合中的关键作用。

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《Neuron》 |2006年第3期|共8页
作者
Plath N; Ohana O; Dammermann B; Errington ML; Schmitz D; Gross C; Mao X; Engelsberg A; Mahlke C; Welzl H; Kobalz U; Stawrakakis A; Fernandez E; Waltereit R; Bick-Sander A; Therstappen E; Cooke SF; Blanquet V; Wurst W; Salmen B; Bosl MR; Lipp HP; Seth G.N. Grant; Tim V.P. Bliss; David P. Wolfer; Dietmar Kuhl;
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正文语种 eng
中图分类神经生理学;
关键词
Cytoskeletal Proteins; Memory; Nerve Tissue Proteins; Neuronal Plasticity; 细胞支架蛋白质类; 记忆; 神经组织蛋白质类; 神经元可塑性; 突触;

机译：Cytoskeletal Proteins;Memory;Nerve Tissue Proteins;Neuronal Plasticity;细胞支架蛋白质类;记忆;神经组织蛋白质类;神经元可塑性;突触;

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1. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. [J] . Plath N, Ohana O, Dammermann B, Neuron . 2006,第3期

机译：Arc / Arg3.1对于巩固突触可塑性和记忆至关重要。
2. A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex. [J] . Gao M, Sossa K, Song L, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2010,第21期

机译：用于视觉体验诱导的小鼠初级视觉皮质中的视觉体验诱导的稳态突触可塑性的特定要求。
3. Platelet-derived Growth Factor-mediated Induction of the Synaptic Plasticity Gene Arc/Arg3.1 [J] . Fuwang Peng, Honghong Yao, Xuetao Bai, The Journal of biological chemistry . 2010,第28期

机译：血小板衍生的生长因子介导的突触塑性基因弧/ arg3.1的诱导
4. THE ROLE OF STRUCTURAL PLASTICITY AND SYNAPTIC CONSOLIDATION FOR MEMORY AND AMNESIA IN A MODEL OF CORTICO-HIPPOCAMPAL INTERPLAY [C] . Neural computation and psychology workshop . 2009

机译：结构可塑性和突触巩固在皮质海马相互作用模型中记忆和突触巩固的作用
5. Mechanisms and functional implications of long-term synaptic plasticity in striatum and network plasticity in hippocampus. [D] . Singla, Sheela. 2007

机译：纹状体中长期突触可塑性和海马中网络可塑性的机制和功能含义。
6. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks [O] . L. Alberi, S. Liu, Y. Wang, -1

机译：在神经元活动诱导的Notch信号传导需要圆弧/ arg3.1并且是用于在网络中海马突触可塑性必不可少
7. Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories [O] . Plath Niels, Ohana Ora, Dammermann Björn, 2006

机译：Arc / Arg3.1对于巩固突触可塑性和记忆至关重要
8. Synaptic Plasticity in Visual Cortex. From Synaptic Properties to Membranes andReceptors [R] . Cooper, L. N. 1995

机译：视觉皮层中的突触可塑性。从突触属性到膜和受体

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

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