TARPs and the AMPA receptor trafficking paradox.

Ziff EB

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TARPs and the AMPA receptor trafficking paradox.

机译：TARPs和AMPA受体贩运悖论。

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AMPA receptors (AMPARs) conduct fast, excitatory currents that depolarize neurons and trigger action potentials. AMPARs took on new importance when it was shown that AMPAR transport can increase or decrease the number of AMPARs at synapses and give rise to synapse plasticity, including long-term potentiation (LTP) and long-term depression (LTD). This review considers how transmembrane AMPAR regulatory proteins (TARPs), a novel family of AMPAR auxiliary subunits, have changed our view of AMPAR transport and raised some perplexing questions.

机译：AMPA受体（AMPAR）传导快速的兴奋性电流，使神经元去极化并触发动作电位。当表明AMPAR转运可增加或减少突触中AMPAR的数量并引起突触可塑性（包括长期增强（LTP）和长期抑郁（LTD））时，AMPA发挥了新的重要性。这篇评论认为跨膜AMPAR调节蛋白（TARPs）是AMPAR辅助亚基的一个新家族，如何改变了我们对AMPAR转运的看法，并提出了一些令人困惑的问题。

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《Neuron》 |2007年第5期|共7页
作者
Ziff EB;
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原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Calcium Channels; Mice; Neurologic Mutants; Protein Transport; Receptors; AMPA; 钙通道; 小鼠; 神经学突变型; 受体; AMPA;

机译：Calcium Channels;Mice;Neurologic Mutants;Protein Transport;Receptors;AMPA;钙通道;小鼠;神经学突变型;受体;AMPA;

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专利

1. TARPs and the AMPA receptor trafficking paradox. [J] . Ziff EB Neuron . 2007,第5期

机译：TARPs和AMPA受体贩运悖论。
2. Stargazin (TARP gamma-2) is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells. [J] . Jackson AC, Nicoll RA The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2011,第11期

机译：小室星状细胞中隔室特异性AMPA受体运输和突触可塑性需要Stargazin（TARP gamma-2）。
3. TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains [J] . Aaron D. Milstein, Roger A. Nicoll Proceedings of the National Academy of Sciences of the United States of America . 2009,第27期

机译：突触AMPA受体运输和门控的TARP调节取决于多个细胞内结构域
4. Optical trapping of quantum-dot conjugated AMPA-type receptors depened on initial assembling states [C] . Tatsunori Kishimoto, Yasuyo Maezawa, Suguru N. Kudoh, SPIE Structured Light Conference . 2018

机译：量子点共轭AMPA型受体的光阱取决于初始组装状态
5. AMPA Glutamate Receptor Trafficking in Models of Disease. [D] . Miller, Eric C. 2013

机译：疾病模型中的AMPA谷氨酸受体贩运。
6. Stargazin (TARP γ-2) Is Required for Compartment-Specific AMPA Receptor Trafficking and Synaptic Plasticity in Cerebellar Stellate Cells [O] . Alexander C. Jackson, Roger A. Nicoll 2011

机译：小室星状细胞中隔室特有的AMPA受体运输和突触可塑性需要Stargazin（TARPγ-2）
7. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating [O] . Shi, Yun, Suh, Young Ho, Milstein, Aaron D., 2010

机译：TARPs和角质蛋白对AMPA受体转运和门控作用的功能比较

TARPs and the AMPA receptor trafficking paradox.

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