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首页> 外文期刊>Neuron >Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
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Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.

机译：CaV（2.3）电压敏感钙通道位于树突棘中的单一突触信号的非线性调节。

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The roles of voltage-sensitive sodium (Na) and calcium (Ca) channels located on dendrites and spines in regulating synaptic signals are largely unknown. Here we use 2-photon glutamate uncaging to stimulate individual spines while monitoring uncaging-evoked excitatory postsynaptic potentials (uEPSPs) and Ca transients. We find that, in CA1 pyramidal neurons in acute mouse hippocampal slices, CaV(2.3) voltage-sensitive Ca channels (VSCCs) are found selectively on spines and act locally to dampen uncaging-evoked Ca transients and somatic potentials. These effects are mediated by a regulatory loop that requires opening of CaV(2.3) channels, voltage-gated Na channels, small conductance Ca-activated potassium (SK) channels, and NMDA receptors. Ca influx through CaV(2.3) VSCCs selectively activates SK channels, revealing the presence of functional Ca microdomains within the spine. Our results suggest that synaptic strength can be modulated by mechanisms that regulate voltage-gated conductances within the spine but do not alter the properties or numbers of synaptic glutamate receptors.
机译：位于树突和棘突上的电压敏感钠（Na）和钙（Ca）通道在调节突触信号中的作用尚不清楚。在这里，我们使用2-光子谷氨酸解笼来刺激单个棘，同时监测解笼诱发的兴奋性突触后电位（uEPSPs）和Ca瞬变。我们发现，在急性小鼠海马切片中的CA1锥体神经元中，有选择地在棘上发现CaV（2.3）电压敏感的Ca通道（VSCC），并在局部起作用，以抑制未诱发的Ca瞬变和体电位。这些影响由需要打开CaV（2.3）通道，电压门控Na通道，小电导Ca活化钾（SK）通道和NMDA受体的调节环介导。 Ca渗透通过CaV（2.3）VSCC选择性激活SK通道，揭示脊柱内功能性Ca微域的存在。我们的结果表明，可以通过调节脊柱内电压门控电导的机制来调节突触强度，但不会改变突触谷氨酸受体的性质或数量。

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