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首页> 外文期刊>Neuron >Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.
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Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

机译：长期的视觉剥夺和视网膜图像恢复后，皮质图和白质束出现。

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Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven years following the surgery, remain severely limited, and he does not rely on vision for daily life. Neuroimaging measurements reveal several differences among MM, sighted controls, sighted monocular, and early blind subjects. We speculate that these differences stem from damage during the critical period in development of retinal neurons with small, foveal receptive fields. In this case, restoration of functional vision requires more than improving retinal image contrast. In general, visual restoration will require accounting for the developmental trajectory of the individual and the consequences of the early deprivation on cortical circuitry.
机译：开发过程中视觉输入异常会对视觉系统产生巨大影响。纠正输入后，成人视觉系统会如何反应？ MM在3岁时因角膜受损而失去了左眼，而在右侧变得失明。在46岁时，MM恢复了视网膜图像，但是即使在手术后七年，他的视力也仍然受到严重限制，他确实不能依靠视觉进行日常生活。神经影像学测量揭示了MM，有视力的对照者，有视力的单眼和早期失明受试者之间的一些差异。我们推测这些差异是由于视网膜中央神经小，中央凹接受区发育的关键时期的损伤引起的。在这种情况下，恢复功能性视力不仅仅需要改善视网膜图像对比度。通常，视觉恢复将需要考虑个体的发展轨迹以及早期剥夺对皮质回路的影响。

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