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首页> 外文期刊>Neuron >Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment.
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Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment.

机译：在新型环境中海马CA1的细胞内决定因素和沉默细胞活性。

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摘要

For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed differences in intrinsic cellular properties and input-based subthreshold membrane potential levels underlying this division into place and silent cells. Compared to silent cells, place cells had lower spike thresholds and peaked versus flat subthreshold membrane potentials as a function of animal location. Both differences were evident from the beginning of exploration. Additionally, future place cells exhibited higher burst propensity before exploration. Thus, internal settings appear to predetermine which cells will represent the next novel environment encountered. Furthermore, place cells fired spatially tuned bursts with large, putatively calcium-mediated depolarizations that could trigger plasticity and stabilize the new map for long-term storage. Our results provide new insight into hippocampal memory formation.
机译：对于啮齿动物探索的每种环境，其海马区都包含一个地图，该地图由一个独特的神经元子集（称为位置细胞）组成，该位置在空间上有尖峰，其余神经元基本上保持沉默。在探索新型迷宫的自由移动大鼠中使用全细胞记录，我们观察了固有细胞特性和基于输入的亚阈值膜电位水平之间的差异，该水平是该细胞分裂和沉默细胞的基础。与沉默细胞相比，放置细胞的尖峰阈值较低，并且与平坦的亚阈值膜电位相比具有峰值，这是动物位置的函数。两种差异从探索之初就显而易见。另外，未来的位置细胞在探索之前表现出更高的爆发倾向。因此，内部设置似乎可以确定哪个单元将代表遇到的下一个新环境。此外，位置细胞会发射带有大的，可能是钙介导的去极化的空间调谐脉冲，这可能触发可塑性并稳定新的长期储存图。我们的结果提供了对海马记忆形成的新见解。

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