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首页> 外文期刊>Neuron >Assembly and Maintenance of Nodes of Ranvier Rely on Distinct Sources of Proteins and Targeting Mechanisms
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Assembly and Maintenance of Nodes of Ranvier Rely on Distinct Sources of Proteins and Targeting Mechanisms

机译：Ranvier节点的组装和维护依赖于不同的蛋白质来源和靶向机制

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We have investigated the source(s) and targeting of components to PNS nodes of Ranvier. We show adhesion molecules are freely diffusible within the axon membrane and accumulate at forming nodes from local sources, whereas ion channels and cytoskeletal components are largely immobile and require transport to the node. We further characterize targeting of NF186, an adhesion molecule that pioneers node formation. NF186 redistributes to nascent nodes from a mobile, surface pool. Its initial accumulation and clearance from the internode require extracellular interactions, whereas targeting to mature nodes, i.e., those flanked by paranodal junctions, requires intracellular interactions. After incorporation into the node, NF186 is immobile, stable, and promotes node integrity. Thus, nodes assemble from two sources: adhesion molecules, which initiate assembly, accumulate by diffusion trapping via interactions with Schwann cells, whereas ion channels and cytoskeletal components accumulate via subsequent transport. In mature nodes, components turnover slowly and are replenished via transport. Video Abstract: Zhang etal provide new insights into the development of nodes of Ranvier. They find assembly is initiated by redistribution of mobile, surface pools of axonal adhesion molecules, whereas ion channels and cytoskeletal components require transport to this site. Once formed, nodes are highly stable.
机译：我们研究了Ranvier的PNS节点的组件来源和定位。我们显示粘附分子可在轴突膜内自由扩散，并在局部来源的形成结点处积聚，而离子通道和细胞骨架成分在很大程度上是不可移动的，需要转运至结点。我们进一步表征NF186的目标，NF186是开创节点形成的粘附分子。 NF186从移动的表面池重新分布到新生节点。其从节间的初始积累和清除需要细胞外相互作用，而靶向成熟节，即旁侧结节侧翼的那些，则需要细胞内相互作用。合并到节点中后，NF186是不动的，稳定的，并提高了节点的完整性。因此，节点从两个来源组装：启动组装的粘附分子通过与雪旺细胞的相互作用通过扩散捕获而积累，而离子通道和细胞骨架成分则通过随后的运输而积累。在成熟节点中，组件周转缓慢，并通过运输进行补充。视频摘要：Zhang etal提供了有关Ranvier节点开发的新见解。他们发现组装是通过轴突粘附分子的可移动表面池的重新分布开始的，而离子通道和细胞骨架成分则需要转运到该部位。一旦形成，节点就非常稳定。

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