The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.

Wills Z; Bateman J; Korey CA; Comer A; Van Vactor-D

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The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.

机译：酪氨酸激酶Abl及其底物能够与受体磷酸酶Dlar协同控制轴突的运动。

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Genetic analysis of growth cone guidance choice points in Drosophila identified neuronal receptor protein tyrosine phosphatases (RPTPs) as key determinants of axon pathfinding behavior. We now demonstrate that the Drosophila Abl tyrosine kinase functions in the intersegmental nerve b (ISNb) motor choice point pathway as an antagonist of the RPTP Dlar. The function of Abl in this pathway is dependent on an intact catalytic domain. We also show that the Abl phosphoprotein substrate Enabled (Ena) is required for choice point navigation. Both Abl and Ena proteins associate with the Dlar cytoplasmic domain and serve as substrates for Dlar in vitro, suggesting that they play a direct role in the Dlar pathway. These data suggest that Dlar, Abl, and Ena define a phosphorylation state-dependent switch that controls growth cone behavior by transmitting signals at the cell surface to the actin cytoskeleton.

机译：果蝇生长锥引导选择点的遗传分析确定神经元受体蛋白酪氨酸磷酸酶（RPTPs）是轴突寻路行为的关键决定因素。我们现在证明，果蝇Abl酪氨酸激酶功能在节间神经b（ISNb）运动选择点途径中作为RPTP Dlar的拮抗剂。 Abl在该途径中的功能取决于完整的催化结构域。我们还显示，选择点导航需要启用Abl磷蛋白底物（Ena）。 Abl和Ena蛋白均与Dlar胞质域结合，并在体外充当Dlar的底物，表明它们在Dlar途径中起直接作用。这些数据表明，Dlar，Abl和Ena定义了一种依赖磷酸化状态的开关，该开关通过将细胞表面的信号传递至肌动蛋白细胞骨架来控制生长锥的行为。

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《Neuron》 |1999年第2期|共12页
作者
Wills Z; Bateman J; Korey CA; Comer A; Van Vactor-D;
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正文语种 eng
中图分类神经生理学;
关键词
Axons; DNA-Binding Proteins; Growth Cones; Motor Neurons; Protein-Tyrosine-Phosphatase; 轴突; DNA结合蛋白质类; 生长锥; 运动神经元; 蛋白质酪氨酸磷酸酶; 原癌基因蛋白质C-ABL类;

机译：Axons;DNA-Binding Proteins;Growth Cones;Motor Neurons;Protein-Tyrosine-Phosphatase;轴突;DNA结合蛋白质类;生长锥;运动神经元;蛋白质酪氨酸磷酸酶;原癌基因蛋白质C-ABL类;

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专利

1. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. [J] . Wills Z, Bateman J, Korey CA, Neuron . 1999,第2期

机译：酪氨酸激酶Abl及其底物能够与受体磷酸酶Dlar协同控制轴突的运动。
2. The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity [J] . Zheng W., Lennartsson J., Hendriks W., Cellular Signalling . 2011,第6期

机译：LAR蛋白酪氨酸磷酸酶可通过减弱c-Abl激酶活性来激活PDGFβ受体
3. A Drosophila homolog of cyclase-associated proteins collaborates with the abl tyrosine kinase to control midline axon pathfinding. [J] . Wills Z, Emerson M, Rusch J, Neuron . 2002,第4期

机译：果蝇与环化酶相关蛋白的同源物与abl酪氨酸激酶协同控制中线轴突寻路。
4. On the role of adenylate cyclase, tyrosine kinase and tyrosine phosphatase in the response of nerve and glial cells to photodynamic impact [C] . M. Kolosov, D. Bragin, O. Dergacheva, Conference on optical technologies in biophysics and medicine . 2004

机译：腺苷酸环酶，酪氨酸激酶和酪氨酸磷酸酶在神经和胶质细胞对光动力撞击响应中的作用
5. Novel mechanisms of NMDA receptor regulation by the tyrosine phosphatase SHP2 and the tyrosine kinase Arg [D] . Levy, Aaron Donald. 2017

机译：酪氨酸磷酸酶SHP2和酪氨酸激酶Arg调节NMDA受体的新机制
6. The Receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila [O] . Jeong K. Song, Edward Giniger, Chand J. Desai -1

机译：受体蛋白酪氨酸磷酸酶PTP69D拮抗Abl酪氨酸激酶以指导果蝇中的轴突。
7. The Tyrosine Kinase Abl and Its Substrate Enabled Collaborate with the Receptor Phosphatase Dlar to Control Motor Axon Guidance [O] . Wills Zachary, Bateman Jack, Korey Christopher A, 1999

机译：酪氨酸激酶Abl及其底物与受体磷酸酶Dlar协同控制轴突的运动。

The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.

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