...
首页> 外文期刊>Neuron >Cortical development and remapping through spike timing-dependent plasticity.
【24h】

Cortical development and remapping through spike timing-dependent plasticity.

机译:皮层发育和通过与时间相关的峰值的可塑性重新映射。

获取原文
获取原文并翻译 | 示例
           

摘要

Long-term modification of synaptic efficacy can depend on the timing of pre- and postsynaptic action potentials. In model studies, such spike timing-dependent plasticity (STDP) introduces the desirable features of competition among synapses and regulation of postsynaptic firing characteristics. STDP strengthens synapses that receive correlated input, which can lead to the formation of stimulus-selective columns and the development, refinement, and maintenance of selectivity maps in network models. The temporal asymmetry of STDP suppresses strong destabilizing self-excitatory loops and allows a group of neurons that become selective early in development to direct other neurons to become similarly selective. STDP, acting alone without further hypothetical global constraints or additional forms of plasticity, can also reproduce the remapping seen in adult cortex following afferent lesions.
机译:突触功效的长期改变可能取决于突触前和突触后动作电位的时间。在模型研究中,这种依赖于尖峰时间的可塑性(STDP)引入了突触之间竞争和突触后放电特性调控的理想特征。 STDP增强了接收相关输入的突触,这可能导致刺激选择性列的形成以及网络模型中选择性图的开发,完善和维护。 STDP的时间不对称性抑制了强烈的不稳定自我兴奋循环,并使一群在发育早期变得具有选择性的神经元能够指导其他神经元具有类似的选择性。 STDP单独采取行动,没有进一步的假设性总体约束或其他形式的可塑性,也可以重现传入皮损后在成人皮层中所见的重映射。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号