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首页> 外文期刊>Neuron >nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures.
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nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures.

机译:nompA编码将机械感觉树突连接到感觉结构所需的PNS特异性ZP域蛋白。

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摘要

Mutations in the no-mechanoreceptor-potential A (nompA) gene, which eliminate transduction in Drosophila mechanosensory organs, disrupt contacts between neuronal sensory endings and cuticular structures. nompA encodes a transmembrane protein with a large, modular extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-terminal (PAN) modules. It is specifically expressed in type I sense organs of the peripheral nervous system by the support cells that ensheath the neuronal sensory process. A green fluorescent protein (GFP)-NompA fusion protein is localized to the dendritic cap, an extracellular matrix that covers the ciliary outer segment of the sensory process and that shows organizational defects in nompA mutants. The structure and location of NompA suggest that it forms part of a mechanical linkage required to transmit mechanical stimuli to the transduction apparatus.
机译:无机械感受器电位A(nompA)基因中的突变消除了果蝇机械感觉器官中的转导,破坏了神经元感觉末梢与表皮结构之间的接触。 nompA编码具有大的模块化细胞外区段的跨膜蛋白,该区段包括透明带(ZP)结构域和几个纤溶酶原N端(PAN)模块。它通过包裹神经元感觉过程的支持细胞在外周神经系统的I型感觉器官中特异性表达。绿色荧光蛋白(GFP)-NompA融合蛋白位于树突状帽上,树突状帽是一种覆盖感觉过程的睫状外段的细胞外基质,在nompA突变体中显示出组织缺陷。 NompA的结构和位置表明,它构成了将机械刺激传递到转导设备所需的机械连接的一部分。

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