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首页> 外文期刊>Neuron >The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala
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The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

机译：恒河猴Connectome预测杏仁核的药物遗传学失活导致功能网络中断。

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摘要

Contemporary research suggests that the mammalian brain is a complex system, implying that damage to even a single functional area could have widespread consequences across the system. To test this hypothesis, we pharmacogenetically inactivated the rhesus monkey amygdala, a subcortical region with distributed and well-defined cortical connectivity. We then examined the impact of that perturbation on global network organization using resting-state functional connectivity MRI. Amygdala inactivation disrupted amygdalocortical communication and distributed corticocortical coupling across multiple functional brain systems. Altered coupling was explained using a graph-based analysis of experimentally established structural connectivity to simulate disconnection of the amygdala. Communication capacity via monosynaptic and polysynaptic pathways, in aggregate, largely accounted for the correlational structure of endogenous brain activity and many of the non-local changes that resulted from amygdala inactivation. These results highlight the structural basis of distributed neural activity and suggest a strategy for linking focal neuropathology to remote neurophysiological changes.
机译：当代研究表明，哺乳动物的大脑是一个复杂的系统，这意味着即使对单个功能区域的损坏也可能在整个系统中造成广泛的后果。为了验证这一假设，我们用药理学使恒河猴杏仁核失活，后者是一个皮质下区域，具有分布式和定义明确的皮质连通性。然后，我们使用静止状态功能连接MRI检查了这种扰动对全球网络组织的影响。杏仁核失活破坏了杏仁核的交流，并在多个功能性脑系统之间分布了皮层皮质耦合。使用基于图的对实验建立的结构连接性进行模拟分析来解释杏仁核分离的方法。总体而言，通过单突触和多突触途径的通讯能力在很大程度上解释了内源性大脑活动的相关结构以及杏仁核失活导致的许多非局部变化。这些结果突出了分布式神经活动的结构基础，并提出了将局灶性神经病理学与远程神经生理学改变联系起来的策略。

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