...
首页> 外文期刊>Neuron >Stimulus timing-dependent plasticity in cortical processing of orientation.
【24h】

Stimulus timing-dependent plasticity in cortical processing of orientation.

机译:在定向的皮层处理中刺激时间依赖于可塑性。

获取原文
获取原文并翻译 | 示例
           

摘要

The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orientation tuning of cat cortical neurons, with the direction of the shift depending on the temporal order of the pair. Induction of a significant shift required that the interval between the pair fall within +/-40 ms, reminiscent of the temporal window for spike timing-dependent synaptic plasticity. Mirroring the plasticity found in cat visual cortex, similar conditioning also induced a shift in perceived orientation by human subjects, further suggesting functional relevance of this phenomenon. Thus, relative timing of visual stimuli can play a critical role in dynamic modulation of adult cortical function, perhaps through spike timing-dependent synaptic plasticity.
机译:突触前和突触后尖峰的相对时间在活动诱导的突触修饰中起关键作用。在这里,我们检查了视皮层中方向选择性的可塑性是否取决于刺激时机。视觉刺激在两个方向上的重复配对导致猫皮层神经元的方向调整发生变化,该变化的方向取决于该对的时间顺序。要产生明显的偏移,需要使两对之间的间隔落在+/- 40 ms之内,这让人想起时间窗,以获取与尖峰时间相关的突触可塑性。反映猫视觉皮层中发现的可塑性,类似的调节也诱导了人类受试者感知方向的转变,进一步表明了这种现象的功能相关性。因此,视觉刺激的相对时机可能在成年皮层功能的动态调节中起关键作用,可能是通过依赖于时机的依赖于突触时机的突触可塑性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号