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首页> 外文期刊>Neuron >Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe.
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Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe.

机译:蝗虫触角异味引起的时间模式的细胞和网络机制模型。

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摘要

Locust antennal lobe (AL) projection neurons (PNs) respond to olfactory stimuli with sequences of depolarizing and hyperpolarizing epochs, each lasting hundreds of milliseconds. A computer simulation of an AL network was used to test the hypothesis that slow inhibitory connections between local neurons (LNs) and PNs are responsible for temporal patterning. Activation of slow inhibitory receptors on PNs by the same GABAergic synapses that underlie fast oscillatory synchronization of PNs was sufficient to shape slow response modulations. This slow stimulus- and neuron-specific patterning of AL activity was resistant to blockade of fast inhibition. Fast and slow inhibitory mechanisms at synapses between LNs and PNs can thus form dynamical PN assemblies whose elements synchronize transiently and oscillate collectively, as observed not only in the locust AL, but also in the vertebrate olfactory bulb.
机译:刺槐触角(AL)投射神经元(PNs)对嗅觉刺激作出反应,以去极化和超极化时期为序,每个持续数百毫秒。 AL网络的计算机模拟用于测试以下假设:局部神经元(LNs)和PNs之间的缓慢抑制连接是造成时间模式的原因。 PN的快速振荡同步所基于的同一GABA能突触激活PN上的慢速抑制受体,足以形成慢响应调制。 AL活动的这种缓慢的刺激和神经元特异性模式抵抗快速抑制的阻滞。因此,不仅在蝗虫AL中,而且在脊椎动物嗅球中都观察到,LN和PN之间突触的快速和慢速抑制机制可以形成动态PN组件,其元素瞬时同步并共同振荡。

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