Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse.

Chen C; Blitz DM; Regehr WG

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Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse.

机译：受体脱敏和饱和度对维甲酸突触可塑性的贡献。

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The retinogeniculate synapse conveys visual information from the retina to thalamic relay neurons. Here, we examine the mechanisms of short-term plasticity that can influence transmission at this connection in mouse brain slices. Our studies show that synaptic strength is modified by physiological activity patterns due to marked depression at high frequencies. Postsynaptic mechanisms of plasticity make prominent contributions to this synaptic depression. During trains of retinal input stimulation, receptor desensitization attenuates the AMPA EPSC while the NMDA EPSC saturates. This differential plasticity may help explain the distinct roles of these receptors in shaping the relay neuron response to visual stimulation with the AMPA component being important for transient responses, while sustained high frequency responses rely more on the NMDA component.

机译：维甲酸突触将视觉信息从视网膜传递到丘脑中继神经元。在这里，我们研究了短期可塑性的机制，该机制可影响小鼠大脑切片中此连接处的传递。我们的研究表明，由于高频下明显的抑郁，生理活动模式会改变突触强度。突触后可塑性的机制对此突触抑郁症作出了突出贡献。在一系列视网膜输入刺激过程中，受体脱敏会减弱AMPA EPSC，而NMDA EPSC会饱和。这种差异的可塑性可能有助于解释这些受体在塑造视觉刺激的中继神经元反应中的独特作用，其中AMPA成分对于瞬时反应很重要，而持续的高频反应则更多地依赖NMDA成分。

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《Neuron》 |2002年第5期|共10页
作者
Chen C; Blitz DM; Regehr WG;
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正文语种 eng
中图分类神经生理学;
关键词
Geniculate Bodies; Neuronal Plasticity; Receptors; AMPA; Receptors; N-Methyl-D-Aspartate; 膝状体; 神经元可塑性; 受体; AMPA; 受体; N-甲基-D-天冬氨酸; 突触; 缬氨酸;

机译：Geniculate Bodies;Neuronal Plasticity;Receptors;AMPA;Receptors;N-Methyl-D-Aspartate;膝状体;神经元可塑性;受体;AMPA;受体;N-甲基-D-天冬氨酸;突触;缬氨酸;

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专利

1. Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse. [J] . Chen C, Blitz DM, Regehr WG Neuron . 2002,第5期

机译：受体脱敏和饱和度对维甲酸突触可塑性的贡献。
2. Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse. [J] . DiGregorio DA, Rothman JS, Nielsen TA, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第31期

机译：小脑苔藓纤维颗粒细胞突触处AMPA受体的脱敏特性。
3. Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse. [J] . DiGregorio DA, Rothman JS, Nielsen TA, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第31期

机译：小脑苔藓纤维颗粒细胞突触处AMPA受体的脱敏特性。
4. A Model of Synaptic Normalization and Heterosynaptic Plasticity Based on Competition for a Limited Supply of AMPA Receptors [C] . Jochen Triesch International conference on artificial neural networks . 2017

机译：基于AMPA受体限量供应竞争的突触标准化和异突触可塑性模型
5. Contributions of the NMDA receptor to plasticity in hippocampal, hippocampo-cortical, and cortical circuits. [D] . Libbey, Megan Elizabeth. 2003

机译：NMDA受体对海马，海马皮质和皮质回路可塑性的贡献。
6. Activity-Dependent Patterning of Retinogeniculate Axons Proceeds with a Constant Contribution from AMPA and NMDA Receptors [O] . Carsten D. Hohnke, Serkan Oray, Mriganka Sur 2000

机译：视视网膜轴突的活动依赖模式由AMPA和NMDA受体持续贡献
7. Contributions of Receptor Desensitization and Saturation to Plasticity at the Retinogeniculate Synapse [O] . Chen Chinfei, Blitz Dawn M., Regehr Wade G. 2002

机译：视网膜脱敏突触的受体脱敏和饱和对可塑性的贡献。

Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse.

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