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首页> 外文期刊>Neuron >Making connections in the fly visual system.
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Making connections in the fly visual system.

机译:在飞行视觉系统中建立连接。

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摘要

Understanding the molecular mechanisms that regulate formation of precise patterns of neuronal connections within the central nervous system remains a challenging problem in neurobiology. Genetic studies in worms and flies and molecular studies in vertebrate systems have led to an increasingly sophisticated understanding of how growth cones navigate toward their targets and form topographic maps. Considerably less is known about how growth cones recognize their cellular targets and form synapses with them. Here, we review connection formation in the fly visual system, the methodological approaches used to study it, and recent progress in uncovering the molecular basis of connection specificity.
机译:理解调节中枢神经系统内神经元连接的精确模式形成的分子机制仍然是神经生物学中一个具有挑战性的问题。蠕虫和苍蝇的遗传研究以及脊椎动物系统的分子研究已使人们越来越了解生长锥如何向其目标导航并形成地形图。关于生长锥如何识别它们的细胞靶标并与其形成突触的了解很少。在这里,我们回顾了飞行视觉系统中的连接形成,用于研究它的方法论方法,以及揭示连接特异性的分子基础的最新进展。

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