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首页> 外文期刊>Neuron >Regulation of cortical dendrite development by Slit-Robo interactions.
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Regulation of cortical dendrite development by Slit-Robo interactions.

机译：Slit-Robo相互作用调节皮质枝晶的发育。

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摘要

Slit proteins have previously been shown to regulate axon guidance, branching, and neural migration. Here we report that, in addition to acting as a chemorepellant for cortical axons, Slit1 regulates dendritic development. Slit1 is expressed in the developing cortex, and exposure to Slit1 leads to increased dendritic growth and branching. Conversely, inhibition of Slit-Robo interactions by Robo-Fc fusion proteins or by a dominant-negative Robo attenuates dendritic branching. Stimulation of neurons transfected with a Met-Robo chimeric receptor with Hepatocyte growth factor leads to a robust induction of dendritic growth and branching, suggesting that Robo-mediated signaling is sufficient to induce dendritic remodeling. These experiments indicate that Slit-Robo interactions may exert a significant influence over the specification of cortical neuron morphology by regulating both axon guidance and dendritic patterning.
机译：以前已经证明狭缝蛋白可调节轴突的引导，分支和神经迁移。在这里我们报告，除了充当皮质轴突的化学驱除剂之外，Slit1还调节树突状发育。 Slit1在发育中的皮层中表达，暴露于Slit1会导致树突状生长和分支增加。相反，通过Robo-Fc融合蛋白或显性负性Robo抑制Slit-Robo相互作用会减弱树突分支。用Met-Robo嵌合受体与肝细胞生长因子转染的神经元的刺激导致树突状生长和分支的强烈诱导，表明Robo介导的信号传导足以诱导树突状重塑。这些实验表明，Slit-Robo相互作用可能通过调节轴突导向和树突模式，对皮层神经元形态的规范产生重大影响。

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