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首页> 外文期刊>Neuron >Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.
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Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.

机译：异突触多巴胺神经传递选择皮质皮质末端的集合。

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Dopamine input to the striatum is required for voluntary motor movement, behavioral reinforcement, and responses to drugs of abuse. It is speculated that these functions are dependent on either excitatory or inhibitory modulation of corticostriatal synapses onto medium spiny neurons (MSNs). While dopamine modulates MSN excitability, a direct presynaptic effect on the corticostriatal input has not been clearly demonstrated. We combined optical monitoring of synaptic vesicle exocytosis from motor area corticostriatal afferents and electrochemical recordings of striatal dopamine release to directly measure effects of dopamine at the level of individual presynaptic terminals. Dopamine released by either electrical stimulation or amphetamine acted via D2 receptors to inhibit the activity of subsets of corticostriatal terminals. Optical and electrophysiological data suggest that heterosynaptic inhibition was enhanced by higher frequency stimulation and was selective for the least active terminals. Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections.
机译：多巴胺输入到纹状体是自愿运动，行为强化和对滥用药物的反应所必需的。据推测，这些功能取决于对皮层神经突触（MSN）的皮质口突触的兴奋性或抑制性调节。尽管多巴胺调节MSN的兴奋性，但尚未明确证明对皮质口输入有直接的突触前作用。我们结合了光学监测运动区皮层皮质传入神经对突触小泡胞吐作用和纹状体多巴胺释放的电化学记录，以直接测量各个突触前末端水平上多巴胺的影响。通过电刺激或苯丙胺释放的多巴胺可通过D2受体发挥作用，从而抑制皮层皮质终末子集的活性。光学和电生理学数据表明，较高频率的刺激增强了异突触抑制作用，并且对最不活跃的末端具有选择性。因此，通过过滤不太活跃的输入，多巴胺似乎可以增强特定的皮质口突触连接。

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