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首页> 外文期刊>Neuron >Regulation of CBP-mediated transcription by neuronal calcium signaling.
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Regulation of CBP-mediated transcription by neuronal calcium signaling.

机译：通过神经元钙信号传导调节CBP介导的转录。

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摘要

The transcription factor CREB is involved in mediating many of the long-term effects of activity-dependent plasticity at glutamatergic synapses. Here, we show that activation of NMDA receptors and voltage-sensitive calcium channels leads to CREB-mediated transcription in cortical neurons via a mechanism regulated by CREB-binding protein (CBP). Recruitment of CBP to the promoter is not sufficient for transactivation, but calcium influx can induce CBP-mediated transcription via two distinct transactivation domains. CBP-mediated transcription is stimulus strength-dependent and can be induced by activation of CaM kinase II, CaM kinase IV, and protein kinase A, but not by activation of the Ras-MAP kinase pathway. These observations indicate that CBP can function as a calcium-sensitive transcriptional coactivator that may act as a regulatory switch for glutamate-induced CREB-mediated transcription.
机译：转录因子CREB参与介导谷氨酸能突触的许多活性依赖性可塑性的长期影响。在这里，我们表明，NMDA受体和电压敏感的钙通道的激活通过CREB结合蛋白（CBP）调控的机制，导致CREB介导的皮层神经元转录。将CBP招募至启动子不足以进行反式激活，但是钙流入可通过两个不同的反式激活结构域诱导CBP介导的转录。 CBP介导的转录是刺激强度依赖性的，可以通过激活CaM激酶II，CaM激酶IV和蛋白激酶A来诱导，但不能通过激活Ras-MAP激酶途径来诱导。这些观察结果表明，CBP可以充当钙敏感的转录共激活剂，可以充当谷氨酸诱导的CREB介导的转录的调控开关。

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