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首页> 外文期刊>Neuron >Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity.
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Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity.

机译：眼优势可塑性期间视觉皮层中眼睛特异性反应的稳态调节。

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Experience-dependent plasticity is crucial for the precise formation of neuronal connections during development. It is generally thought to depend on Hebbian forms of synaptic plasticity. In addition, neurons possess other, homeostatic means of compensating for changes in sensory input, but their role in cortical plasticity is unclear. We used two-photon calcium imaging to investigate whether homeostatic response regulation contributes to changes of eye-specific responsiveness after monocular deprivation (MD) in mouse visual cortex. Short MD durations decreased deprived-eye responses in neurons with binocular input. Longer MD periods strengthened open-eye responses, and surprisingly, also increased deprived-eye responses in neurons devoid of open-eye input. These bidirectional response adjustments effectively preserved the net visual drive for each neuron. Our finding that deprived-eye responses were either weaker or stronger after MD, depending on the amount of open-eye input a cell received, argues for both Hebbian and homeostatic mechanisms regulating neuronal responsiveness during experience-dependent plasticity.
机译：依赖于经验的可塑性对于发育过程中神经元连接的精确形成至关重要。通常认为它依赖于Hebbian形式的突触可塑性。此外，神经元还具有其他稳态机制来补偿感觉输入的变化，但是它们在皮质可塑性中的作用尚不清楚。我们使用两光子钙成像来研究稳态视觉响应调节是否有助于小鼠视皮层单眼剥夺（MD）后眼睛特异性响应的变化。短的MD持续时间会减少双眼输入的神经元的弱视眼反应。较长的MD时期会增强睁眼​​反应，令人惊讶的是，在没有睁眼输入的神经元中，无视眼反应也会增加。这些双向响应调整有效地保留了每个神经元的净视觉驱动力。我们的发现，MD后视力丧失的能力减弱或增强，这取决于接受细胞睁眼输入的数量，这证明了Hebbian和体内平衡机制在经验依赖的可塑性过程中调节神经元的反应能力。

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