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首页> 外文期刊>Neuron >New experiences enhance coordinated neural activity in the hippocampus.
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New experiences enhance coordinated neural activity in the hippocampus.

机译：新的经验增强了海马中协调的神经活动。

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摘要

The acquisition of new memories for places and events requires synaptic plasticity in the hippocampus, and plasticity depends on temporal coordination among neurons. Spatial activity in the hippocampus is relatively disorganized during the initial exploration of a novel environment, however, and it is unclear how neural activity during the initial stages of learning drives synaptic plasticity. Here we show that pairs of CA1 cells that represent overlapping novel locations are initially more coactive and more precisely coordinated than are cells representing overlapping familiar locations. This increased coordination occurs specifically during brief, high-frequency events (HFEs) in the local field potential that are similar to ripples and is not associated with better coordination of place-specific neural activity outside of HFEs. As novel locations become more familiar, correlations between cell pairs decrease. Thus, hippocampal neural activity during learning has a unique structure that is well suitedto induce synaptic plasticity and to allow for rapid storage of new memories.
机译：获取有关地点和事件的新记忆需要海马体中的突触可塑性，而可塑性取决于神经元之间的时间协调。然而，在新环境的初始探索过程中，海马的空间活动相对混乱，而且尚不清楚在学习的初始阶段神经活动如何驱动突触可塑性。在这里，我们显示代表重叠的新位置的CA1细胞对最初比代表重叠的熟悉位置的细胞更具有主动性和更精确地协调。这种增强的协调性特别是在局部场电势中的短暂高频事件（HFE）期间发生，该事件类似于波纹，并且与HFEs外部的特定地点神经活动的更好协调无关。随着新颖的位置变得越来越熟悉，细胞对之间的相关性降低。因此，学习过程中的海马神经活动具有独特的结构，非常适合于诱导突触可塑性并允许快速存储新的记忆。

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