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首页> 外文期刊>Neuron >Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
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Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.

机译：针对海马回路无活动的突触特定适应可实现稳态增益控制，同时抑制网络混响。

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摘要

Synaptic homeostasis, induced by chronic changes in neuronal activity, is well studied in cultured neurons, but not in more physiological networks where distinct synaptic circuits are preserved. We characterized inactivity-induced adaptations at three sets of excitatory synapses in tetrodotoxin-treated organotypic hippocampal cultures. The adaptation to inactivity was strikingly synapse specific. Hippocampal throughput synapses (dentate-to-CA3 and CA3-to-CA1) were upregulated, conforming to homeostatic gain control in order to avoid extreme limits of neuronal firing. However, chronic inactivity decreased mEPSC frequency at CA3-to-CA3 synapses, which were isolated pharmacologically or surgically. This downregulation of recurrent synapses was opposite to that expected for conventional homeostasis, in apparent conflict with typical gain control. However, such changes contributed to an inactivity-induced shortening of reverberatory bursts generated by feedback excitation among CA3 pyramids, safeguarding the network from possible runaway excitation. Thus, synapse-specific adaptations of synaptic weight not only contributed to homeostatic gain control, but also dampened epileptogenic network activity.
机译：由神经元活动的慢性变化引起的突触体内稳态在培养的神经元中得到了很好的研究，但在保留了独特突触回路的更多生理网络中却没有得到很好的研究。我们在河豚毒素治疗的器官型海马文化中表征了三组兴奋性突触的不活动诱导的适应。对不活动的适应是突触特异性的。海马吞吐量突触（齿到CA3和CA3到CA1）被上调，符合稳态增益控制，以避免神经元放电的极限。但是，长期不活动会降低CA3-TO-CA3突触的mEPSC频率，这些突触是通过药理学或手术方法分离的。复发性突触的这种下调与常规稳态所预期的相反，与典型的增益控制明显冲突。但是，这种变化导致CA3金字塔之间的反馈激励所产生的非活动性引起的回响脉冲缩短，从而保护了网络免受可能的失控激励。因此，突触重量的突触特定适应不仅有助于稳态增益控制，而且还削弱了癫痫发生网络的活动。

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