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首页> 外文期刊>Neuron >Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses.
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Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses.

机译：下丘脑谷氨酸突触的星形胶质细胞介导的分布可塑性。

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摘要

Afferent activity can induce fast, feed-forward changes in synaptic efficacy that are synapse specific. Using combined electrophysiology, caged molecule photolysis, and Ca(2+) imaging, we describe a plasticity in which the recruitment of astrocytes in response to afferent activity causes a fast and feed-forward, yet distributed increase in the amplitude of quantal synaptic currents at multiple glutamate synapses on magnocellular neurosecretory cells in the hypothalamic paraventricular nucleus. The plasticity is largely multiplicative, consistent with a proportional increase or "scaling" in the strength of all synapses on the neuron. This effect requires a metabotropic glutamate receptor-mediated rise in Ca(2+) in the astrocyte processes surrounding the neuron and the release of the gliotransmitter ATP, which acts on postsynaptic purinergic receptors. These data provide evidence for a form of distributed synaptic plasticity that is feed-forward, expressed quickly, and mediated by the synaptic activation of neighboring astrocytes.
机译：传入活动可以诱导突触特异性的突触功效快速，前馈变化。使用组合的电生理学，笼状分子光解法和Ca（2+）成像，我们描述了一种可塑性，其中星形胶质细胞响应传入活动的募集导致快速和前馈，但在数量上的突触电流振幅的分布增加下丘脑室旁核的大细胞神经分泌细胞上发生多个谷氨酸突触。可塑性在很大程度上是可乘的，与神经元上所有突触强度的成比例增加或“成比例”一致。此效果需要在神经元周围的星形胶质细胞过程中由代谢型谷氨酸受体介导的Ca（2+）的升高和神经胶质递质ATP的释放，后者作用于突触后嘌呤能受体。这些数据提供了一种形式的分布突触可塑性的证据，该形式可前馈，快速表达并由邻近星形胶质细胞的突触激活介导。

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