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首页> 外文期刊>Neuron >FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling.
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FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling.

机译：FARP1通过跨膜Semaphorin6A和PlexinA4信号传导促进脊髓运动神经元亚型的树突生长。

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摘要

The dendritic morphology of neurons dictates their abilities to process and transmit information; however, the signaling pathways that regulate dendritic growth and complexity are poorly understood. Here, we show that retinoids induce the expression of the FERM Rho-GEF protein FARP1 in the developing spinal cord. FARP1 is expressed in subsets of motor neurons and is enriched in dendrites of lateral motor column (LMC) neurons that innervate the limb. FARP1 is necessary and sufficient to promote LMC dendritic growth but does not affect dendrite number or axonal morphology. We show that FARP1 serves as a specific effector of transmembrane Semaphorin6A and PlexinA4 signals to regulate LMC dendritic growth, and that its Rho-GEF domain is necessary for this function. These findings reveal that retinoid and Sema6A/PlexA4 signaling pathways intersect through FARP1 to control dendritic growth, and uncover the existence of subtype-specific signaling networks that control dendritic developmental programs in spinal motor neurons.
机译：神经元的树突形态决定了它们处理和传递信息的能力。然而，调节树突状生长和复杂性的信号通路知之甚少。在这里，我们显示类维生素A诱导发育中的脊髓中的FERM Rho-GEF蛋白FARP1的表达。 FARP1在运动神经元的子集中表达，并在支配肢体的侧运动柱（LMC）神经元的树突中富集。 FARP1是促进LMC树突状生长所必需的，但不影响树突数或轴突形态。我们表明，FARP1充当跨膜Semaphorin6A和PlexinA4信号的特定效应物，以调节LMC树突状生长，并且其Rho-GEF结构域对该功能至关重要。这些发现表明，类维生素A和Sema6A / PlexA4信号通路通过FARP1相交以控制树突状细胞的生长，并揭示了控制脊髓运动神经元中树突状发育程序的亚型特异性信号网络的存在。

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