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首页> 外文期刊>Neuron >State-dependent spike-timing relationships between hippocampal and prefrontal circuits during sleep.
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State-dependent spike-timing relationships between hippocampal and prefrontal circuits during sleep.

机译：睡眠期间海马和前额叶回路之间的状态相关性穗定时关系。

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摘要

Cortico-hippocampal interactions during sleep are believed to reorganize neural circuits in support of memory consolidation. However, spike-timing relationships across cortico-hippocampal networks-key determinants of synaptic changes-are poorly understood. Here we show that cells in prefrontal cortex fire consistently within 100 ms after hippocampal cells in naturally sleeping animals. This provides evidence at the single cell-pair level for highly consistent directional interactions between these areas within the window of plasticity. Moreover, these interactions are state dependent: they are driven by hippocampal sharp-wave/ripple (SWR) bursts in slow-wave sleep (SWS) and are sharply reduced during REM sleep. Finally, prefrontal responses are nonlinear: as the strength of hippocampal bursts rises, short-latency prefrontal responses are augmented by increased spindle band activity and a secondary peak approximately 100 ms later. These findings suggest that SWR events are atomic units of hippocampal-prefrontal communication during SWS and that the coupling between these areas is highly attenuated during REM sleep.
机译：睡眠期间皮质-海马相互作用被认为重组神经回路以支持记忆巩固。然而，人们对皮质-海马网络之间的峰-定时关系（突触变化的关键决定因素）了解得很少。在这里，我们显示自然睡眠动物海马细胞后，前额叶皮层中的细胞始终在100毫秒内持续发射。这为可塑性窗口内这些区域之间高度一致的方向相互作用提供了单细胞对水平的证据。此外，这些相互作用与状态有关：它们是由慢波睡眠（SWS）的海马锐波/涟漪（SWR）爆发驱动的，而在REM睡眠过程中则急剧减少。最后，前额叶反应是非线性的：随着海马爆发强度的增加，梭形带活动性增强和大约100 ms后的次要峰会增强短时前额叶反应。这些发现表明，SWR事件是SWS期间海马-前额通讯的原子单元，并且在REM睡眠期间这些区域之间的耦合被大大减弱。

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