The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.

Tsurudome K; Tsang K; Liao EH; Ball R; Penney J; Yang JS; Elazzouzi F; He T; Chishti A; Lnenicka G; Lai EC; Haghighi AP

首页> 外文期刊>Neuron >The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.

【24h】

The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.

机译：果蝇miR-310簇负调节神经肌肉接头处的突触强度。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Emerging data implicate microRNAs (miRNAs) in the regulation of synaptic structure and function, but we know little about their role in the regulation of neurotransmission in presynaptic neurons. Here, we demonstrate that the miR-310-313 cluster is required for normal synaptic transmission at the Drosophila larval neuromuscular junction. Loss of miR-310-313 cluster leads to a significant enhancement of neurotransmitter release, which can be rescued with temporally restricted expression of mir-310-313 in larval presynaptic neurons. Kinesin family member, Khc-73 is a functional target for miR-310-313 as its expression is increased in mir-310-313 mutants and reducing it restores normal synaptic function. Cluster mutants show an increase in the active zone protein Bruchpilot accompanied by an increase in electron dense T bars. Finally, we show that repression of Khc-73 by miR-310-313 cluster influences the establishment of normal synaptic homeostasis. Our findings establish a role for miRNAs in the regulation of neurotransmitter release.

机译：新兴数据暗示了microRNA（miRNA）调控突触结构和功能，但我们对其在突触前神经元神经传递调控中的作用了解甚少。在这里，我们证明了果蝇幼虫神经肌肉连接处正常突触传递需要miR-310-313簇。 miR-310-313簇的丢失导致神经递质释放的显着增强，可以通过在幼虫突触前神经元中暂时限制mir-310-313的表达来挽救神经递质的释放。 Kinesin家族成员Khc-73是miR-310-313的功能靶标，因为它在mir-310-313突变体中的表达增加，而其表达降低则恢复了正常的突触功能。簇状突变体显示出活性区蛋白Bruchpilot的增加，伴随着电子致密T条的增加。最后，我们证明了miR-310-313簇抑制Khc-73会影响正常突触稳态的建立。我们的发现确定了miRNA在调节神经递质释放中的作用。

著录项

来源
《Neuron》 |2010年第5期|共15页
作者
Tsurudome K; Tsang K; Liao EH; Ball R; Penney J; Yang JS; Elazzouzi F; He T; Chishti A; Lnenicka G; Lai EC; Haghighi AP;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词

相似文献

外文文献
中文文献
专利

1. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. [J] . Tsurudome K, Tsang K, Liao EH, Neuron . 2010,第5期

机译：果蝇miR-310簇负调节神经肌肉接头处的突触强度。
2. Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction [J] . Amy Tsai, Bryan Stewart, Wade Parkhouse, Biology Open . 2014,第12期

机译：磷酸调节的果蝇adducin是与幼虫神经肌肉连接处的Dlg和PIP2形成复合体的突触可塑性的决定因素磷酸调节的果蝇adducin是与幼虫神经肌肉连接处的Dlg和PIP2形成复合体的突触可塑性的决定因素。 adducin是幼虫神经肌肉交界处与Dlg和PIP2形成复合体的突触可塑性的决定因素
3. Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse [J] . Lita Durraine, Russell S. Hamilton, Ilan Davis, Biology Open . 2014,第9期

机译：Syncrip / hnRNP Q影响果蝇神经肌肉突触的突触传递并调节BMP信号Syncrip / hnRNP Q影响果蝇神经肌肉突触的突触传递并调节BMP信号Syncrip / hnRNP Q影响果蝇神经肌肉突触的突触传递和调节BMP信号。
4. Synaptic Cleft Segmentation in Non-isotropic Volume Electron Microscopy of the Complete Drosophila Brain [C] . Larissa Heinrich, Jan Funke, Constantin Pape, International conference on medical imaging computing and computer-assisted intervention . 2018

机译：果蝇大脑完整的非全同量电子显微镜中的突触裂裂分割。
5. A microRNA cluster negatively regulates synaptic function at Drosophila larval neuromuscular junction. [D] . Tsang, Kai Wai Karen. 2009

机译：microRNA簇负调节果蝇幼虫神经肌肉连接处的突触功能。
6. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction [O] . Kazuya Tsurudome, Karen Tsang, Edward H. Liao, -1

机译：果蝇的miR-310簇神经肌肉接头处负调节突触强度
7. The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction [O] . Tsurudome Kazuya, Tsang Karen, Liao Edward H., 2010

机译：果蝇miR-310群集负调节神经肌肉交界处的突触强度。

The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.

摘要

著录项

相似文献

相关主题

期刊订阅