...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Multimodal integration in granule cells as a basis for associative plasticity and sensory prediction in a cerebellum-like circuit.
【24h】

Multimodal integration in granule cells as a basis for associative plasticity and sensory prediction in a cerebellum-like circuit.

机译：颗粒细胞中的多峰整合作为小脑样回路中联想可塑性和感官预测的基础。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The recoding of diverse sensory and motor signals by granule cells (GCs) is probably critical for the function of cerebellar circuits, yet the nature of these transformations and their significance for cerebellar information processing remain poorly understood. In cerebellum-like structures in fish, anti-Hebbian plasticity at parallel fiber synapses generates "negative images" that act to cancel predictable patterns of electrosensory input. Here I test the hypothesis that GCs enhance the capacity of Purkinje-like cells to generate specific negative images by selectively encoding combinations of sensory and motor signals. Using in vivo whole-cell recordings, I show (1) that a subset of GCs integrate sensory and motor signals conveyed by distinct mossy fiber classes and (2) that Purkinje-like cells exhibit plastic changes specific to the combinations of signals that individual GCs encode. Consistent with influential theories of cerebellar function, these findings suggest that selective GC output enhances the capacity of Purkinje-like cells to acquire selectivity through associative plasticity.
机译：颗粒细胞（GC）对各种感觉和运动信号的重新编码可能对小脑回路的功能至关重要，但是这些转换的性质及其对小脑信息处理的意义仍然知之甚少。在鱼类的小脑样结构中，平行纤维突触处的抗希伯可塑性产生“负像”，其作用是抵消可预测的电感应输入模式。在这里，我测试了以下假设：GC通过选择性编码感觉信号和运动信号的组合来增强浦肯野样细胞产生特定负像的能力。使用体内全细胞记录，我发现（1）GC的一个子集整合了由不同苔藓纤维类别传达的感觉和运动信号，以及（2）Purkinje样细胞表现出特定于单个GC信号组合的塑性变化编码。与小脑功能的影响理论相一致，这些发现表明选择性GC输出增强了Purkinje样细胞通过缔合可塑性获得选择性的能力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号