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首页> 外文期刊>Neuron >Temporally Precise Cell-Specific Coherence Develops in Corticostriatal Networks during Learning
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Temporally Precise Cell-Specific Coherence Develops in Corticostriatal Networks during Learning

机译：在学习过程中在皮质口神经网络中发展出暂时精确的细胞特异性相干性

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It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behavioral output. We investigated coherence between primary motor cortex and the dorsal striatum as rats learn an abstract operant task. Striking coherence developed between these regions during learning. Interestingly, coherence was selectively increased in cells controlling behavioral output relative to adjacent cells. Furthermore, the temporal offset of these interactions aligned closely with corticostriatal conduction delays, demonstrating highly precise timing. Spikes from either region were followed by a consistent phase in the other, suggesting that network feedback reinforces coherence. Together, these results demonstrate that temporally precise coherence develops during learning specifically in output-relevant neuronal populations and further suggest that correlations in oscillatory activity serve to synchronize widespread brain networks to produce behavior.
机译：据推测，神经元之间的选择性时间协调和功能性神经元组装的发展对于大脑功能和行为至关重要。但是，几乎没有证据表明功能相关的协调优先出现在直接控制行为输出的神经元程序集中。当大鼠学习抽象操作任务时，我们调查了主运动皮层和背侧纹状体之间的连贯性。在学习过程中，这些区域之间形成了惊人的连贯性。有趣的是，相对于相邻细胞，在控制行为输出的细胞中有选择地增加了相干性。此外，这些相互作用的时间偏移与皮质口传导延迟紧密一致，表明计时非常精确。来自任一区域的尖峰之后是另一个区域的一致阶段，这表明网络反馈增强了一致性。总之，这些结果表明，在学习期间，特别是在与输出相关的神经元群体中，会出现时间精确的连贯性，并且进一步表明，振荡活动的相关性有助于使广泛的大脑网络同步以产生行为。

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