...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Fear and Safety Engage Competing Patterns of Theta-Gamma Coupling in the Basolateral Amygdala
【24h】

Fear and Safety Engage Competing Patterns of Theta-Gamma Coupling in the Basolateral Amygdala

机译：基底外侧杏仁核Theta-Gamma耦合的恐惧与安全参与竞争模式

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Theta oscillations synchronize the basolateral amygdala (BLA) with the hippocampus (HPC) and medial prefrontal cortex (mPFC) during fear expression. The role of gamma-frequency oscillations in the BLA is less well characterized. We examined gamma-and theta-frequency activity in recordings of neural activity from the BLA-HPC-mPFC circuit during fear conditioning, extinction, and exposure to an open field. In the BLA, slow (40-70 Hz) and fast (70-120 Hz) gamma oscillations were coupled to distinct phases of the theta cycle and reflected synchronous high-frequency unit activity. During periods of fear, BLA theta-fast gamma coupling was enhanced, while fast gamma power was suppressed. Periods of relative safety were associated with enhanced BLA fast gamma power, mPFC-to-BLA directionality, and strong coupling of BLA gamma to mPFC theta. These findings suggest that switches between states of fear and safety are mediated by changes in BLA gamma coupling to competitive theta frequency inputs.
机译：在恐惧表达期间，Theta振荡使基底外侧杏仁核（BLA）与海马（HPC）和内侧前额叶皮层（mPFC）同步。伽马频率振荡在BLA中的作用不太清楚。我们在恐惧调节，消光和暴露于开阔视野期间，检查了BLA-HPC-mPFC电路的神经活动记录中的伽马和θ频率活动。在BLA中，缓慢的（40-70 Hz）和快速的（70-120 Hz）伽马振荡耦合到theta周期的不同相位，并反映了同步的高频单位活动。在恐惧期间，BLA theta-快速伽玛耦合得到增强，而快速伽玛强度被抑制。相对安全期与增强的BLA快速伽马功率，mPFC到BLA的方向性以及BLA伽马与mPFC theta的强耦合有关。这些发现表明，恐惧状态和安全状态之间的转换是由BLA伽玛值变化与竞争性theta频率输入耦合所介导的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号