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首页> 外文期刊>Neuron >Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5
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Hebbian and Homeostatic Plasticity Mechanisms in Regular Spiking and Intrinsic Bursting Cells of Cortical Layer 5

机译：皮质层5的常规突刺和内在爆发细胞的Hebbian和体内稳态可塑性机制

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摘要

Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical projections, and intrinsic bursting cells (IB), which have subcortical projections. Little is known about the plasticity processes and specifically the molecular mechanisms by which these two cell classes develop and maintain their unique integrative properties. In this study, we find that RS and IB cells show fundementally different experience-dependent plasticity processes and integrate Hebbian and homeostatic components of plasticity differently. Both RS and IB cells showed TNF alpha-dependent homeostatic plasticity in response to sensory deprivation, but IB cells were capable of a much faster synaptic depression and homeostatic rebound than RS cells. Only IB cells showed input-specific potentiation that depended on CaMKII autophosphorylation. Our findings demonstrate that plasticity mechanisms are not uniform within the neocortex, even within a cortical layer, but are specialized within subcircuits.
机译：第5层包含新皮层的主要投射神经元，由两种主要细胞类型组成：具有皮质皮质投射的常规尖峰（RS）细胞和具有皮质皮质投射的固有爆发细胞（IB）。关于这两种细胞类型发展并维持其独特整合特性的可塑性过程，尤其是分子机理，人们所知甚少。在这项研究中，我们发现RS和IB细胞从根本上表现出不同的依赖经验的可塑性过程，并且不同程度地整合了Hebbian和体内稳态的可塑性成分。 RS和IB细胞均表现出对TNFα依赖性的对感觉剥夺的稳态可塑性，但是IB细胞比RS细胞具有更快的突触抑制和稳态反弹的能力。仅IB细胞显示出依赖于CaMKII自身磷酸化的输入特异性增强。我们的发现表明，可塑性机制在新皮层内甚至在皮层内均不统一，但在子回路内特异。

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