BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Schubert Christian R.; ODonnell Patricio; Quan Jie; Wendland Jens R.; Xi Hualin S.; Winslow Ashley R.; Domenici Enrico; Essioux Laurent; Kam-Thong Tony; Airey David C.; Calley John N.; Collier David A.; Wang Hong; Eastwood Brian; Ebert Philip; Liu Yushi; Nisenbaum Laura; Ruble Cara; Scherschel James; Smith Ryan Matthew; Qian Hui-Rong; Merchant Kalpana; Didriksen Michael; Matsumoto Mitsuyuki; Saito Takeshi; Brandon Nicholas J.; Cross Alan J.; Wang Qi; Manji Husseini; Kolb Hartmuth; Furey Maura; Drevets Wayne C.; Shin Joo Heon; Jaffe Andrew E.; Jia Yankai; Straub Richard E.; Deep-Soboslay Amy; Hyde Thomas M.; Kleinman Joel E.; Weinberger Daniel R.

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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

机译：BrainSeq：神经基因组学驱动神经精神疾病的新型靶标发现

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We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-forprofit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.

机译：我们概述了一个雄心勃勃的项目，以表征人类主要生命在精神疾病和对照样本中不同大脑区域中转录的多个方面的遗传和表观遗传学调控。最初专注于精神分裂症和情绪障碍，该财团的目标是阐明遗传关联的潜在分子机制，以鉴定新的治疗靶标。该财团目前由七家制药公司和一家非营利性医学研究机构组成，该研究机构作为竞争前的团队工作，以生成和分析与神经精神疾病有关的公开可用的档案大脑基因组数据。

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《Neuron》 |2015年第6期|共6页
作者
Schubert Christian R.; ODonnell Patricio; Quan Jie; Wendland Jens R.; Xi Hualin S.; Winslow Ashley R.; Domenici Enrico; Essioux Laurent; Kam-Thong Tony; Airey David C.; Calley John N.; Collier David A.; Wang Hong; Eastwood Brian; Ebert Philip; Liu Yushi; Nisenbaum Laura; Ruble Cara; Scherschel James; Smith Ryan Matthew; Qian Hui-Rong; Merchant Kalpana; Didriksen Michael; Matsumoto Mitsuyuki; Saito Takeshi; Brandon Nicholas J.; Cross Alan J.; Wang Qi; Manji Husseini; Kolb Hartmuth; Furey Maura; Drevets Wayne C.; Shin Joo Heon; Jaffe Andrew E.; Jia Yankai; Straub Richard E.; Deep-Soboslay Amy; Hyde Thomas M.; Kleinman Joel E.; Weinberger Daniel R.;
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正文语种 eng
中图分类神经病学;
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1. BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders [J] . Schubert Christian R., ODonnell Patricio, Quan Jie, Neuron . 2015,第6期

机译：BrainSeq：神经基因组学驱动神经精神疾病的新型靶标发现
2. Targeting dynamic interplay among disordered domains or endophenotypes to understand complex neuropsychiatric disorders: Translational lessons from preclinical models [J] . Kalueff Allan V., Stewart Adam Michael, Song Cai, Neuroscience and Biobehavioral Reviews . 2015,第Null期

机译：针对无序域或内表型之间的动态相互作用，以了解复杂的神经精神疾病：临床前模型的翻译课程
3. Targeting dynamic interplay among disordered domains or endophenotypes to understand complex neuropsychiatric disorders: Translational lessons from preclinical models [J] . Kalueff Allan V., Stewart Adam Michael, Song Cai, Neuroscience and Biobehavioral Reviews . 2015,第Null期

机译：靶向无序结构域或内胚术之间的动态相互作用，以了解复杂的神经精神疾病：临床前模型的翻译教训
4. A General End-to-End Method for Characterizing Neuropsychiatric Disorders using Free-Viewing Visual Scanning Tasks [C] . Hong Yue Sean Liu, Jonathan Chung, Moshe Eizenman International Conference on Pattern Recognition . 2021

机译：使用自由观察视觉扫描任务表征神经精神障碍的一般端到端方法
5. A rare variant approach to gene discovery in neuropsychiatric disorders [D] . O'Roak, Brian James 2009

机译：神经精神疾病中一种罕见的基因发现变异方法
6. Functional Coding Variation in the Presynaptic Dopamine Transporter Associated with Neuropsychiatric Disorders Drives Enhanced Motivation and Context-Dependent Impulsivity in Mice [O] . Gwynne L. Davis, Adele Stewart, Gregg D. Stanwood, -1

机译：与神经精神障碍相关的突触前多巴胺转运蛋白的功能编码变化驱动小鼠的动机和上下文相关的冲动。
7. BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders [O] . Schubert Christian R., O’Donnell Patricio, Quan Jie, 2015

机译：BrainSeq：神经基因组学驱动神经精神疾病的新型靶标发现

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

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