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首页> 外文期刊>Neuron >Pioneering axons regulate neuronal polarization in the developing cerebral cortex
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Pioneering axons regulate neuronal polarization in the developing cerebral cortex

机译：开拓性的轴突调节发育中的大脑皮层的神经元极化。

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摘要

The polarization of neurons, which mainly includes the differentiation of axons and dendrites, is regulated by cell-autonomous and non-cell-autonomous factors. In the developing central nervous system, neuronal development occurs in a heterogeneous environment that also comprises extracellular matrices, radial glial cells, and neurons. Although many cell-autonomous factors that affect neuronal polarization have been identified, the microenvironmental cues involved in neuronal polarization remain largely unknown. Here, we show that neuronal polarization occurs in a microenvironment in the lower intermediate zone, where the cell adhesion molecule transient axonal glycoprotein-1 (TAG-1) is expressed in cortical efferent axons. The immature neurites ofmultipolar cells closely contact TAG-1-positive axons and generate axons. Inhibition of TAG-1-mediated cell-to-cell interaction or its downstream kinase Lyn impairs neuronal polarization. These results show that the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1.
机译：神经元的极化主要包括轴突和树突的分化，由细胞自主和非细胞自主因子调节。在发育中的中枢神经系统中，神经元发育发生在异质环境中，异质环境还包括细胞外基质，放射状神经胶质细胞和神经元。尽管已经确定了影响神经元极化的许多细胞自治因素，但涉及神经元极化的微环境提示仍然未知。在这里，我们显示神经元极化发生在较低的中间区域的微环境中，那里的细胞粘附分子瞬时轴突糖蛋白-1（TAG-1）在皮质传出的轴突中表达。多极细胞的未成熟神经突紧密接触TAG-1阳性轴突并产生轴突。抑制TAG-1介导的细胞间相互作用或其下游激酶Lyn损害神经元极化。这些结果表明，未极化的多极细胞与先锋轴突之间的TAG-1介导的细胞间相互作用部分地通过Lyn激酶和Rac1调节了多极细胞的极化。

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