...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Simultaneous Encoding of Odors by Channels with Diverse Sensitivity to Inhibition
【24h】

Simultaneous Encoding of Odors by Channels with Diverse Sensitivity to Inhibition

机译：对抑制具有不同敏感性的通道对气味的同时编码

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Odorant receptors in the periphery map precisely onto olfactory glomeruli ("coding channels'') in the brain. However, the odor tuning of a glomerulus is not strongly correlated with its spatial position. This raises the question of whether lateral inhibition between glomeruli is specific or nonspecific. Here we show that, in the Drosophila brain, focal activation of even a single glomerulus recruits GABAergic interneurons in all glomeruli. Moreover, the relative level of interneuron activity in different glomeruli is largely odor invariant. Although interneurons are recruited nonspecifically, glomeruli differ dramatically in their sensitivity to interneuron activity, and this is explained by their varying sensitivity to GABA. Interestingly, a stimulus is typically encoded in parallel by channels having high and low sensitivity to inhibition. Because lateral inhibition confers both costs and benefits, the brain might rely preferentially on "high'' and "low'' channels in different behavioral contexts.
机译：周围的气味受体精确地映射到大脑中的嗅觉肾小球（“编码通道”），但是，肾小球的气味调节与其空间位置并没有强烈的相关性，这引发了一个问题，即肾小球之间的侧向抑制是否是特异性的在这里，我们表明，在果蝇大脑中，即使单个肾小球的局灶性激活也会在所有肾小球中募集GABA能神经元，此外，不同肾小球中神经元活性的相对水平在很大程度上是气味不变的。它们对中间神经元活性的敏感性差异很大，这可以通过它们对GABA的敏感性不同来解释，有趣的是，刺激通常由对抑制具有高和低敏感性的通道并行编码，因为侧向抑制会给大脑带来成本和收益。可能会优先依赖行为不同的“高”和“低”渠道口头语境。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号