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首页> 外文期刊>Neuron >Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex
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Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex

机译：运动学习巩固了次级运动皮层中表达电弧的神经元集合。

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Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed that lesion or inactivation of the secondary motor (M2) cortex disrupts learning of skilled movements. We tracked the endogenous promoter activity of the neuronal activity-regulated gene Arc in individual M2 neurons during rotarod learning by in vivo two-photon imaging of a knockin reporter. We found that task training initially recruits Arc-promoter-activated neurons and then consolidates them into a specific ensemble exhibiting persistent reactivation of Arc-promoter. The intensity of a neuron's initial Arc-promoter activation predicts its reactivation probability and neurons with weak initial Arc-promoter activation are dismissed from the ensemble during subsequent training. Our findings demonstrate a task-specific Arc-dependent cellular consolidation process in M2 cortex during motor learning.
机译：运动行为在运动皮质中募集特定于任务的神经元集合，并在随后的学习中得到巩固。然而，对于可以识别参与的神经元并预测巩固过程结果的分子知之甚少。使用鼠标旋转脚踏车学习任务，我们显示了次级运动（M2）皮层的病变或失活会破坏熟练运动的学习。我们通过敲入记者的体内双光子成像，在轮状动物学习期间跟踪了单个M2神经元中神经元活性调节基因Arc的内源性启动子活性。我们发现，任务训练最初会募集Arc-promoter激活的神经元，然后将它们合并为一个展示了Arc-promoter持续激活的特定集合。神经元的初始Arc启动子激活的强度可预测其重新激活的可能性，而初始Arc启动子激活较弱的神经元在随后的训练中会从整体中解散。我们的发现证明了运动学习过程中M2皮质中特定于任务的弧依赖性细胞整合过程。

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