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首页> 外文期刊>Neuron >CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period.
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CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period.

机译：在发育关键期，CRE介导的基因转录在新皮层神经元可塑性中。

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摘要

Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synaptic rearrangement during a postnatal developmental window, the critical period. Here, using transgenic mice carrying a CRE-lacZ reporter, we demonstrate that a calcium- and cAMP-regulated signaling pathway is activated following monocular deprivation. We find that monocular deprivation leads to an induction of CRE-mediated lacZ expression in the visual cortex preceding the onset of physiologic plasticity, and this induction is dramatically downregulated following the end of the critical period. These results suggest that CRE-dependent coordinate regulation of a network of genes may control physiologic plasticity during postnatal neocortical development.
机译：据信神经元活动依赖性过程介导新皮层发育过程中突触连接的形成，但潜在的细胞内机制尚不清楚。在视觉系统中，通过单眼剥夺改变视觉驱动的神经元活动的模式会在出生后的发育期（关键时期）引起皮质突触重排。在这里，使用携带CRE-lacZ报告基因的转基因小鼠，我们证明了单眼剥夺后激活了钙和cAMP调节的信号通路。我们发现单眼剥夺导致生理可塑性发作之前视觉皮层中CRE介导的lacZ表达的诱导，并且在关键时期结束后，这种诱导显着下调。这些结果表明，基因网络的CRE依赖性协调调控可能在出生后新皮层发育过程中控制生理可塑性。

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