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首页> 外文期刊>Neuron >Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.
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Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.

机译：Caspr2是神经毒素超家族的新成员，位于髓鞘轴突的近旁节，并与K +通道相关。

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摘要

Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that this neurexin-like protein and the closely related molecule Caspr/Paranodin demarcate distinct subdomains in myelinated axons. While contactin-associated protein (Caspr) is present at the paranodal junctions, Caspr2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. We further show that Caspr2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. This association involves the C-terminal sequence of Caspr2, which contains a putative PDZ binding site. These results suggest a role for Caspr family members in the local differentiation of the axon into distinct functional subdomains.
机译：髓鞘轴突中的快速传导取决于不同的离子通道集所定位的专门的亚细胞结构域。在这里，我们描述了果蝇神经毒素IV（Nrx-IV）的哺乳动物同系物Caspr2的鉴定，并显示了这种神经毒素样蛋白与密切相关的分子Caspr / Paranodin在有髓轴突中界定了不同的亚结构域。虽然接触蛋白相关蛋白（Caspr）存在于结节旁的交界处，但Caspr2恰好与近旁结节区中的Shaker样K +通道共定位。我们进一步表明，Caspr2与Kv1.1，Kv1.2及其Kvbeta2亚基特异性结合。这种关联涉及Caspr2的C端序列，其中包含一个推定的PDZ结合位点。这些结果表明，Caspr家族成员在轴突向不同功能亚域的局部分化中发挥作用。

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