The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

Kuan CY; Yang DD; Samanta Roy-DR; Davis RJ; Rakic P; Flavell RA

首页> 外文期刊>Neuron >The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

【24h】

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

机译：Jnk1和Jnk2蛋白激酶是早期大脑发育过程中区域特异性细胞凋亡所必需的。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The c-Jun NH2-terminal kinase (Jnk) family is implicated in apoptosis, but its function in brain development is unclear. Here, we address this issue using mutant mice lacking different members of the family (Jnk1, Jnk2, and Jnk3). Mice deficient in Jnk1, Jnk2, Jnk3, and Jnk1/Jnk3 or Jnk2/Jnk3 double mutants all survived normally. Compound mutants lacking Jnk1 and Jnk2 genes were embryonic lethal and had severe dysregulation of apoptosis in brain. Specifically, there was a reduction of cell death in the lateral edges of hindbrain prior to neural tube closure. In contrast, increased apoptosis and caspase activation were found in the mutant forebrain, leading to precocious degeneration. These results suggest that Jnk1 and Jnk2 regulate region-specific apoptosis during early brain development.

机译：c-Jun NH2末端激酶（Jnk）家族与细胞凋亡有关，但在脑发育中的功能尚不清楚。在这里，我们使用缺少该家族不同成员（Jnk1，Jnk2和Jnk3）的突变小鼠来解决此问题。缺乏Jnk1，Jnk2，Jnk3和Jnk1 / Jnk3或Jnk2 / Jnk3双重突变体的小鼠均正常存活。缺乏Jnk1和Jnk2基因的复合突变体具有胚胎致死性，并且在脑中具有严重的细胞凋亡失调。具体而言，在神经管闭合之前，后脑外侧边缘的细胞死亡减少。相反，在突变的前脑中发现凋亡增加和胱天蛋白酶激活，导致性早熟变性。这些结果表明，Jnk1和Jnk2在早期大脑发育过程中调节区域特异性凋亡。

著录项

来源
《Neuron》 |1999年第4期|共10页
作者
Kuan CY; Yang DD; Samanta Roy-DR; Davis RJ; Rakic P; Flavell RA;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Apoptosis; Brain; Ca2+ Calmodulin Dependent Protein Kinase metabolism; Protein Kinases; 脱噬作用; 脑; 蛋白激酶类;

机译：Apoptosis;Brain;Ca2+ Calmodulin Dependent Protein Kinase metabolism;Protein Kinases;脱噬作用;脑;蛋白激酶类;

相似文献

外文文献
中文文献
专利

1. 烟草花粉发育过程中的细胞凋亡及其与钙/钙调素依赖性蛋白激酶T1表达的关系 [J] . 王玲, 王盈, 张美, 发育与生殖生物学学报（英文版） . 2001,第001期
2. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. [J] . Kuan CY, Yang DD, Samanta Roy-DR, Neuron . 1999,第4期

机译：Jnk1和Jnk2蛋白激酶是早期大脑发育过程中区域特异性细胞凋亡所必需的。
3. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons [J] . Eric J. DOWNER, Marie P. FOGARTY, Veronica CAMPBELL The biochemical journal . 2003,第3期

机译：c-Jun N末端激酶1（JNK1）而非JNK2在β-淀粉样蛋白介导的蛋白p53稳定化和诱导培养的皮质神经元凋亡级联中的作用
4. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons [J] . Fogarty MP., Downer EJ., Campbell V. The Biochemical Journal . 2003,第Pta3期

机译：c-Jun N末端激酶1（JNK1）而非JNK2在β-淀粉样蛋白介导的蛋白p53稳定化和诱导培养的皮质神经元凋亡级联中的作用
5. Protein Kinase C δ Promotes Cell Apoptosis Induced by High Fluence Low-Power Laser Irradiation [C] . Heng Zhang, Da Xing, Shengnan Wu, Photonics and imaging in biology and medicine . 2009

机译：蛋白激酶Cδ促进高通量低功率激光辐照诱导的细胞凋亡
6. Role of G-protein coupled receptor kinase interacting protein 1 (GIT1) in bone homeostasis and brain development. [D] . Menon, Prashanthi. 2010

机译：G蛋白偶联受体激酶相互作用蛋白1（GIT1）在骨骼稳态和大脑发育中的作用。
7. c-Jun N-Terminal Protein Kinase 1 (JNK1) but Not JNK2 Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis [O] . Jing Liu, Yuzuru Minemoto, Anning Lin 2004

机译：c-Jun N末端蛋白激酶1（JNK1）而不是JNK2对于肿瘤坏死因子α诱导的c-Jun激酶激活和凋亡至关重要
8. The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development [O] . Kuan Chia-Yi, Yang Derek D., Roy Deborah R.Samanta, 1999

机译：Jnk1和Jnk2蛋白激酶是早期大脑发育过程中区域特异性凋亡所必需的
9. Neuron-Specific Protein F1/GAP-43 Shows Substrate Specificity for the BetaSubtype of Protein Kinase C [R] . Sheu, F. S., Marais, R. M., Parker, P. J., 1990

机译：神经元特异性蛋白F1 / Gap-43显示蛋白激酶C的β亚型的底物特异性

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

摘要

著录项

相似文献

相关主题

期刊订阅