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首页> 外文期刊>Neuron >Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation.
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Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation.

机译：预测可卡因的线索诱发的复发取决于快速，短暂的突触增强。

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摘要

Cocaine addiction is characterized by long-lasting vulnerability to relapse arising because neutral environmental stimuli become associated with drug use and then act as cues that induce relapse. It is not known how cues elicit cocaine seeking, and why cocaine seeking is more difficult to regulate than seeking a natural reward. We found that cocaine-associated cues initiate cocaine seeking by inducing a rapid, transient increase in dendritic spine size and synaptic strength in the nucleus accumbens. These changes required neural activity in the prefrontal cortex. This is not the case when identical cues were associated with obtaining sucrose, which did not elicit changes in spine size or synaptic strength. The marked cue-induced synaptic changes in the accumbens were correlated with the intensity of cocaine, but not sucrose seeking, and may explain the difficulty addicts experience in managing relapse to cocaine use.
机译：可卡因成瘾的特征在于持久的易复发性，因为中性环境刺激与吸毒相关，然后作为诱发复发的线索。目前尚不清楚线索是如何引起可卡因搜寻的，以及为什么可卡因搜寻比寻求自然奖励更难调节。我们发现可卡因相关的线索通过诱导伏隔核中树突棘的大小和突触强度的快速而短暂的增加而引发可卡因的寻找。这些变化需要额叶前额叶的神经活动。当相同的提示与获得蔗糖相关联时，情况并非如此，这并未引起脊柱大小或突触强度的改变。提示中伏安诱发的突触引起的突触变化与可卡因的强度相关，但与寻求蔗糖无关，并且可以解释成瘾者在处理可卡因使用复发方面的困难。

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